Impact of pretransplant body mass index on early kidney graft function
| Autor: | J. Drozdrowski, Michal Wszola, Andrzej Chmura, K. Jędrzejko, Monika Bieniasz, D. Zygier, Leszek Pączek, Jolanta Gozdowska, Rafal Kieszek, Magdalena Durlik, Artur Kwiatkowski, Aleksandra Tomaszek, Piotr Domagala |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Graft Rejection Male Reoperation medicine.medical_specialty Adolescent Urology Renal function Delayed Graft Function Body Mass Index chemistry.chemical_compound Young Adult Risk Factors Odds Ratio Medicine Humans Obesity Kidney transplantation Aged Retrospective Studies Aged 80 and over Transplantation Creatinine business.industry Incidence (epidemiology) Incidence Graft Survival Retrospective cohort study Odds ratio Middle Aged medicine.disease Kidney Transplantation Surgery Treatment Outcome chemistry Kidney Failure Chronic Female business Body mass index Follow-Up Studies |
| Zdroj: | Transplantation proceedings. 46(8) |
| ISSN: | 1873-2623 |
| Popis: | An increase in the number of obese patients on transplantation waiting lists can be observed. There are conflicting results regarding the influence of body mass index (BMI) on graft function.We performed a single-center, retrospective study of 859 adult patients who received a renal graft from deceased donors. BMI (kg/m(2)) was calculated from patients' height and weight at the time of transplantation. Kidney recipients were subgrouped into 4 groups, according to their BMI: Groups A (18.5; n = 57), B (18.6-24.9; n = 565), C (25-29.9; n = 198) and D (30; n = 39). Primary or delayed graft function (DGF), acute rejection (AR) episodes, and number of reoperations, graft function expressed by glomerular filtration rate (GFR) and serum creatinine concentration and number of graft loss as well as the recipient's death were analyzed. The follow-up period was 1 year.Obese patients' grafts do not develop any function more frequently in comparison with their nonobese counterparts (P.0001; odds ratio [OR], 32.364; 95% CI, 2.174-941.422). Other aspects of the procedure were analyzed to confirm that thesis: Cold ischemia time and number of HLA mismatches affect the frequency of AR (OR, 1.0182 [P = .0029] and OR, 1.1496 [P = .0147], respectively); moreover, donor median creatinine serum concentration (P = .00004) and cold ischemia time (P = .00019) are related to delayed graft function. BMI did not influence the incidence of DGF (P = .08, OR; 1.167; 95% CI, 0.562-2.409), the number of AR episodes (P.1; OR, 1.745; 95% CI, 0.846-3.575), number of reoperations, GFR (P = .22-.92), or creatinine concentration (P = .09). Number of graft losses (P = .12; OR, 1.8; 95% CI, 0.770-4.184) or patient deaths (P = .216; OR, 3.69; 95% CI, 0.153-36.444) were not influenced.Greater recipient BMI at the time of transplantation has a significant influence on the incidence of primary graft failure. |
| Databáze: | OpenAIRE |
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