Proton nuclear magnetic resonance imaging of regionally ischemic canine hearts: effect of paramagnetic proton signal enhancement
Autor: | I L Pykett, W S Hinshaw, M R Goldman, Jeffrey H. Newhouse, J. Philip Kistler, Gerald M. Pohost, Ferdinando S. Buonanno, Thomas J. Brady, C.Tyler Burt |
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Rok vydání: | 1982 |
Předmět: |
Male
Materials science Magnetic Resonance Spectroscopy Proton Biomedical Engineering Biophysics Ischemia chemistry.chemical_element Coronary Disease Manganese Models Biological Paramagnetism Dogs Nuclear magnetic resonance medicine Animals Radiology Nuclear Medicine and imaging Myocardial infarction medicine.diagnostic_test business.industry Magnetic resonance imaging Steady-state free precession imaging medicine.disease Intensity (physics) Signal enhancement Radiographic Image Enhancement chemistry Evaluation Studies as Topic Proton NMR Female Tomography Protons business Nuclear medicine |
Zdroj: | Radiology. 144:343-347 |
ISSN: | 1527-1315 0033-8419 |
DOI: | 10.1148/radiology.144.2.6283594 |
Popis: | In a study to evaluate the potential of proton nuclear magnetic resonance (NMR) imaging with and without manganese contrast with and without manganese contrast enhancement for detecting acute myocardial infarction, 12 dogs underwent 90-minute occlusion of the left circumflex coronary artery. Transverse-section NMR images of the excised, nonbeating heart were obtained at 1-cm intervals using the steady-state-free-precession (SSFP) technique. All NMR images revealed detailed structure of the heart. The three hearts without manganese showed no difference in intensity between the normal and the ischemic posterior regions, whereas those with manganese demonstrated a clearly demarcated zone of reduced signal intensity consistent with the ischemic zone. It is concluded that high-resolution tomograms of the excised canine myocardium can be obtained using proton NMR imaging. With the SSFP imaging technique, proton signal enhancement with manganese infusion is necessary to differentiate between ischemic and nonischemic myocardium after 90 minutes of coronary occlusion. |
Databáze: | OpenAIRE |
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