Targeted Theranostic Approach for Glioma Using Dendrimer-Based Curcumin Nanoparticle
| Autor: | Meser M. Ali, Nipuni Dhanesha H Gamage, M J Worsham, Li Jing |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Biomedical Engineering Glioma specific agent Pharmaceutical Science Medicine (miscellaneous) Nanoparticle Bioengineering Pharmacology Dendritic curcumin conjugate Article Optical imaging 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Glioma Dendrimer medicine Aqueous medium Chemistry medicine.disease Enhanced bioavailability 3. Good health 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Curcumin Nanotheranostic Nanomedicine Conjugate |
| Zdroj: | Journal of nanomedicine & nanotechnology |
| ISSN: | 2157-7439 |
| Popis: | The delivery of anti-cancer agents to brain tumors represent a challenge because the blood-brain tumor barrier (BBTB) effectively limits the delivery of many agents. A new generation 3 (G3) dendrimer-based curcumin (Curc) conjugate was synthesized. The synthesized G3-Curc conjugate demonstrated full solubility in aqueous media. The in vitro study revealed that G3-Curc nanoparticles were internalized into glioma U-251 cells. Systemic delivery of G3-Curc conjugate led to preferentially accumulation in an orthotopic preclinical glioma model minimizing systemic toxic effect. Multicolor microscopy images of the tumor tissue showed that G3-Curc particles were internalized inside tumor cells selectively and further localized within nuclei. Enhanced bioavailability of G3-Curc conjugate was also observed with improved therapeutic efficacy against different cancers cells. |
| Databáze: | OpenAIRE |
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