The Importance of Tablet Formulation on Allergen Release Kinetics and Efficiency: Comparison of Freeze-dried and Compressed Grass Pollen Sublingual Allergy Immunotherapy Tablet Formulations
| Autor: | Simon Lawton, Kaare Lund, Hirokazu Kito, Mette Blem Skydtsgaard, Hiroshi Nakazawa, Katsuyo Ohashi-Doi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Allergy
medicine.medical_treatment 02 engineering and technology 030204 cardiovascular system & hematology medicine.disease_cause Poaceae 03 medical and health sciences 020210 optoelectronics & photonics 0302 clinical medicine Allergen immune system diseases Grass pollen otorhinolaryngologic diseases 0202 electrical engineering electronic engineering information engineering Medicine Pharmacology (medical) Sublingual immunotherapy Pharmacology Active ingredient Sublingual Immunotherapy Chromatography Small volume business.industry Immunotherapy respiratory system Allergens medicine.disease Rhinitis Allergic respiratory tract diseases Kinetics Freeze Drying Efficiency comparison Pollen business Tablets |
| Zdroj: | Clinical therapeutics. 41(4) |
| ISSN: | 1879-114X |
| Popis: | Purpose Efficient delivery of allergens to the sublingual mucosa is a prerequisite for successful sublingual immunotherapy (SLIT) for allergy, and in order to become available to immune-competent cells embedded in the sublingual mucosa, allergens need to be delivered in a soluble form. Delivery of solubilized allergens poses a particular challenge for tablet-based allergy immunotherapy, in which allergens are administered under the tongue in the form of dry tablets and need to be dissolved rapidly in a small volume of saliva, with little or no agitation. The purposes of this article were to compare the properties of 2 different pharmaceutical SLIT-tablet formulations, freeze-dried and compressed, and to examine how the tablet formulation affects the efficiency with which allergen is delivered from the dry state of the tablet into soluble form. Methods Two SLIT-tablet formulations, both indicated for grass pollen allergic rhinitis and containing grass pollen extract as the active ingredient, were examined with regard to tablet disintegration times, allergen dissolution kinetics, dependency on solvent volume and agitation, and the achieved recovery of the grass allergen content in soluble form with each tablet. Findings The freeze-dried and the compressed SLIT-tablet formulations differed markedly with respect to efficiency of allergen release. The freeze-dried tablet disintegrated faster and released grass allergen into solution with a release rate higher than that of the compressed formulation and, in contrast to the compressed formulation, achieved full recovery of the allergen content in soluble form in a small volume of solvent. Implications Rapid and complete release of soluble allergen in a small volume of solvent, as demonstrated by the freeze-dried formulation, are key elements of efficient sublingual allergen delivery by SLIT-tablets. Complete allergen release means that the full allergen dose of the tablet is recovered from the tablet and made available to the sublingual immune system in soluble form, and rapid release ensures that the immune system becomes exposed to the highest possible dose of soluble allergen for the maximal duration before swallowing. In contrast, a SLIT-tablet formulation that provides incomplete and slower allergen release will likely require a higher allergen content compared to the more efficient formulation, in order to achieve the same dose of soluble allergen, consequently leading to an excess load of allergen that becomes swallowed without having been made immunologically available. |
| Databáze: | OpenAIRE |
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