Targeting Lysyl Oxidase Family Meditated Matrix Cross-Linking as an Anti-Stromal Therapy in Solid Tumours
| Autor: | Yordanos F I Setargew, Kaitlin Wyllie, Jessica L. Chitty, Rhiannon D. Grant, Thomas R. Cox |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Stromal cell extracellular matrix Lysyl oxidase Review Matrix (biology) medicine.disease_cause lcsh:RC254-282 Extracellular matrix Medicine cancer integumentary system business.industry Disease progression Cancer medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens anti-stromal targeting enzymes and coenzymes (carbohydrates) tumorigenesis Oncology Cancer research business Carcinogenesis tumour microenvironment lysyl oxidases |
| Zdroj: | Cancers, Vol 13, Iss 491, p 491 (2021) Cancers |
| ISSN: | 2072-6694 |
| Popis: | Simple Summary To improve efficacy of solid cancer treatment, efforts have shifted towards targeting both the cancer cells and the surrounding tumour tissue they grow in. The lysyl oxidase (LOX) family of enzymes underpin the fibrotic remodeling of the tumour microenvironment to promote both cancer growth, spread throughout the body and modulate response to therapies. This review examines how the lysyl oxidase family is involved in tumour development, how they can be targeted, and their potential as diagnostic and prognostic biomarkers in solid tumours. Abstract The lysyl oxidase (LOX) family of enzymes are a major driver in the biogenesis of desmoplastic matrix at the primary tumour and secondary metastatic sites. With the increasing interest in and development of anti-stromal therapies aimed at improving clinical outcomes of cancer patients, the Lox family has emerged as a potentially powerful clinical target. This review examines how lysyl oxidase family dysregulation in solid cancers contributes to disease progression and poor patient outcomes, as well as an evaluation of the preclinical landscape of LOX family targeting therapeutics. We also discuss the suitability of the LOX family as a diagnostic and/or prognostic marker in solid tumours. |
| Databáze: | OpenAIRE |
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