Network spectra for drug-target identification in complex diseases: new guns against old foes
| Autor: | Sarika Jalan, Aparna Rai, Pramod Shinde |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Structure (mathematical logic) Molecular interactions Multidisciplinary Computer Networks and Communications Systems biology lcsh:T57-57.97 Drug target Network spectra Network science Review 01 natural sciences Data science 03 medical and health sciences Computational Mathematics 030104 developmental biology 0103 physical sciences Disease networks lcsh:Applied mathematics. Quantitative methods Random matrix theory (RMT) Identification (biology) Adjacency matrix 010306 general physics Biomarkers |
| Zdroj: | Applied Network Science, Vol 3, Iss 1, Pp 1-18 (2018) Applied Network Science |
| ISSN: | 2364-8228 |
| Popis: | The fundamental understanding of altered complex molecular interactions in a diseased condition is the key to its cure. The overall functioning of these molecules is kind of jugglers play in the cell orchestra and to anticipate these relationships among the molecules is one of the greatest challenges in modern biology and medicine. Network science turned out to be providing a successful and simple platform to understand complex interactions among healthy and diseased tissues. Furthermore, much information about the structure and dynamics of a network is concealed in the eigenvalues of its adjacency matrix. In this review, we illustrate rapid advancements in the field of network science in combination with spectral graph theory that enables us to uncover the complexities of various diseases. Interpretations laid by network science approach have solicited insights into molecular relationships and have reported novel drug targets and biomarkers in various complex diseases. |
| Databáze: | OpenAIRE |
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