Expression and localization of fibroblast growth factor (FGF)23 and Klotho in the spleen: its physiological and functional implications

Autor:	Yoshiyuki Hanba, Yuri Nakashima, Tomohiro Sonou, Koichi Tatsuta, Daisuke Koreeda, Mitsuru Yashiro, Mari Moribata, Shintaro Yamanaka, Toru Mima, Takashi Shigematsu, Shigeo Negi, Asuka Masumoto, Masaki Ohya
Rok vydání:	2016
Předmět:	Male 0301 basic medicine medicine.medical_specialty Clinical Biochemistry CD11c Spleen urologic and male genital diseases Fibroblast growth factor Flow cytometry Mice 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Splenocyte Animals Klotho Proteins Klotho Glucuronidase B-Lymphocytes medicine.diagnostic_test biology hemic and immune systems Dendritic Cells Cell Biology Marginal zone Receptors Fibroblast Growth Factor female genital diseases and pregnancy complications Cell biology Fibroblast Growth Factors Mice Inbred C57BL Fibroblast Growth Factor-23 stomatognathic diseases 030104 developmental biology medicine.anatomical_structure CD1D biology.protein 030215 immunology
Zdroj:	Growth Factors. 34:196-202
ISSN:	1029-2292 0897-7194
DOI:	10.1080/08977194.2016.1273222
Popis:	The FGF23-Klotho signaling axis is known to exert anti-aging effects via calcium-phosphorus metabolism. In mice deficient in FGF23-Klotho signaling, however, the number of splenocytes is reduced. FGF23 is expressed in both bone and spleen, with regulation of its production differing in these organs. As FGF23-Klotho signaling may play an immunological role in the spleen, splenocytes in male C57BL/6J mice were assayed for expression of Klotho or FGF23 by flow cytometry and immunohistochemistry. Cells that expressed Klotho included CD45R/B220+ CD21/CD35+ CD1d+ CD43- marginal zone B cells. These cells also expressed FGF receptor 1, indicating that Klotho-positive B cells could respond to FGF23. Plasmacytoid dendritic cells (pDCs) with CD11c+ CD45R/B220+ CD11b- CD8α- were found to produce FGF23. Klotho-positive cells and FGF23-producing cells were present in close proximity to each other, suggesting that FGF23 produced by pDCs may act within a limited area. These findings indicate that FGF23-Klotho signaling could play a biological or immunological role in the spleen.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fcb8d44ac05613c6a51b563123c542 https://doi.org/10.1080/08977194.2016.1273222 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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