Unusual compounds from Galium mollugo and their inhibitory activities against ROS generation in human fibroblasts

Autor: Eric Pedrot, Tristan Richard, Djebbar Atmani, Jean-Michel Mérillon, Stéphanie Krisa, Jean-Claude Delaunay, Nassima Chaher, Stéphane Bernillon
Přispěvatelé: Faculté des Sciences de la Nature et de la Vie, Institut des Sciences de la Vigne et du Vin (ISVV), Biologie du fruit et pathologie (BFP), Université Sciences et Technologies - Bordeaux 1-Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Plant Components
Stereochemistry
Cell Survival
Clinical Biochemistry
Human fibroblasts
Pharmaceutical Science
Inhibitory postsynaptic potential
Mollugoside
Antioxidants
Analytical Chemistry
Galium
Galium mollugo
03 medical and health sciences
Drug Discovery
[SDV.BV]Life Sciences [q-bio]/Vegetal Biology
Humans
Spectroscopy
Cell survival
Cells
Cultured
chemistry.chemical_classification
Flavonoids
Reactive oxygen species
biology
Dose-Response Relationship
Drug
Plant Extracts
fungi
food and beverages
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
Fibroblasts
Plant Components
Aerial
biology.organism_classification
Dioxatricyclodecenone
030104 developmental biology
chemistry
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Reactive Oxygen Species
Two-dimensional nuclear magnetic resonance spectroscopy
Zdroj: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2016, 117, pp.79-84. ⟨10.1016/j.jpba.2015.07.027⟩
ISSN: 0731-7085
DOI: 10.1016/j.jpba.2015.07.027⟩
Popis: International audience; Three unusual dioxatricyclodecenone compounds, mollugoside A, E-mollugoside B and Z-mollugoside B and, together with known flavonoids, were isolated from the aerial parts of Galium mollugo collected in north-eastern Algeria. Their structures were elucidated by analysis of spectroscopic data, including 1D and 2D NMR. Flavonoids and mollugoside A significantly reduced reactive oxygen species (ROS) generation in human fibroblasts.
Databáze: OpenAIRE
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