Effects of betaine on non-alcoholic liver disease
| Autor: | Minwen Xu, Yucai Wang, Liefeng Wang, Weiqiang Chen, Minjuan Xu, Shuixiang Xie, Qingyan Zou |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Medicine (miscellaneous) Disease medicine.disease_cause Pathogenesis chemistry.chemical_compound Betaine Insulin resistance Non-alcoholic Fatty Liver Disease Internal medicine Humans Medicine Nutrition and Dietetics business.industry Lipogenesis Fatty liver AMPK medicine.disease Endocrinology Liver chemistry Insulin Resistance business Oxidative stress |
| Zdroj: | Nutrition Research Reviews. 35:28-38 |
| ISSN: | 1475-2700 0954-4224 |
| DOI: | 10.1017/s0954422421000056 |
| Popis: | The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) poses a growing challenge in terms of its prevention and treatment. The ‘multiple hits’ hypothesis of multiple insults, such as dietary fat intake, de novo lipogenesis, insulin resistance, oxidative stress, mitochondrial dysfunction, gut dysbiosis and hepatic inflammation, can provide a more accurate explanation of the pathogenesis of NAFLD. Betaine plays important roles in regulating the genes associated with NAFLD through anti-inflammatory effects, increased free fatty oxidation, anti-lipogenic effects and improved insulin resistance and mitochondrial function; however, the mechanism of betaine remains elusive. |
| Databáze: | OpenAIRE |
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