Estimation of the dietary requirement for vitamin D in healthy adults
| Autor: | Mairead Kiely, Maria S. Barnes, Tom R. Hill, Geraldine Horigan, Anthony P. Fitzgerald, Nicola Taylor, Maxine P. Bonham, Julie M. W. Wallace, Kelly M. Seamans, Alice J. Lucey, Kevin D. Cashman, Albert Flynn, S Muldowney, Emeir M. Duffy, J. J. Strain |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Vitamin Gerontology Ultraviolet Rays Medicine (miscellaneous) Enzyme-Linked Immunosorbent Assay Dietary vitamin Nutrition Policy Vitamin d 3 Young Adult chemistry.chemical_compound Animal science Double-Blind Method Reference Values Vitamin D and neurology Humans Medicine Vitamin D Cholecalciferol Sunlight Nutrition and Dietetics Bone Density Conservation Agents Dose-Response Relationship Drug business.industry Nutritional Requirements Intervention studies Dose–response relationship chemistry Dietary Supplements Female Seasons Sun exposure business |
| Zdroj: | The American Journal of Clinical Nutrition. 88:1535-1542 |
| ISSN: | 0002-9165 |
| DOI: | 10.3945/ajcn.2008.26594 |
| Popis: | Knowledge gaps have contributed to considerable variation among international dietary recommendations for vitamin D.We aimed to establish the distribution of dietary vitamin D required to maintain serum 25-hydroxyvitamin D [25(OH)D] concentrations above several proposed cutoffs (ie, 25, 37.5, 50, and 80 nmol/L) during wintertime after adjustment for the effect of summer sunshine exposure and diet.A randomized, placebo-controlled, double-blind 22-wk intervention study was conducted in men and women aged 20-40 y (n = 238) by using different supplemental doses (0, 5, 10, and 15 microg/d) of vitamin D(3) throughout the winter. Serum 25(OH)D concentrations were measured by using enzyme-linked immunoassay at baseline (October 2006) and endpoint (March 2007).There were clear dose-related increments (P0.0001) in serum 25(OH)D with increasing supplemental vitamin D(3). The slope of the relation between vitamin D intake and serum 25(OH)D was 1.96 nmol x L(-1) x microg(-1) intake. The vitamin D intake that maintained serum 25(OH)D concentrations of25 nmol/L in 97.5% of the sample was 8.7 microg/d. This intake ranged from 7.2 microg/d in those who enjoyed sunshine exposure, 8.8 microg/d in those who sometimes had sun exposure, and 12.3 microg/d in those who avoided sunshine. Vitamin D intakes required to maintain serum 25(OH)D concentrations of37.5,50, and80 nmol/L in 97.5% of the sample were 19.9, 28.0, and 41.1 microg/d, respectively.The range of vitamin D intakes required to ensure maintenance of wintertime vitamin D status [as defined by incremental cutoffs of serum 25(OH)D] in the vast majority (97.5%) of 20-40-y-old adults, considering a variety of sun exposure preferences, is between 7.2 and 41.1 microg/d. |
| Databáze: | OpenAIRE |
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