Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease
| Autor: | Yoshio Sumida, Hajime Nakamura, Takaharu Yoh, Takeshi Okanoue, Junji Yodoi, Akihisa Hirohama, Hironori Mitsuyoshi, Kei Kashima, Yoshiki Nakajima, Toshiaki Nakashima, Masanori Furutani, Yuko Kakisaka, Hiroki Ishikawa |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology animal structures Adolescent Iron medicine.disease_cause Severity of Illness Index digestive system Gastroenterology Hepatitis Pathogenesis Thioredoxins Predictive Value of Tests Internal medicine Nonalcoholic fatty liver disease medicine Humans Clinical significance Aged Hepatology biology business.industry Case-control study nutritional and metabolic diseases Middle Aged medicine.disease digestive system diseases Fatty Liver Ferritin Liver ROC Curve Case-Control Studies Ferritins biology.protein Female Steatohepatitis Thioredoxin business Oxidative stress |
| Zdroj: | Journal of Hepatology. 38:32-38 |
| ISSN: | 0168-8278 |
| DOI: | 10.1016/s0168-8278(02)00331-8 |
| Popis: | Thioredoxin (TRX) is a stress-inducible thiol-containing protein. The aim of this study was to evaluate the clinical significance of serum TRX in patients with nonalcoholic steatohepatitis (NASH) or simple steatosis.Serum TRX levels were determined using an enzyme-linked immunosorbent assay kit in 25 patients with NASH, 15 patients with simple steatosis, and 17 healthy volunteers.Serum TRX levels (medians and (ranges), ng/ml) were significantly elevated in patients with NASH (60.3 (17.6-104.7)), compared to those in patients with simple steatosis (24.6 (16.6-69.7), P=0.0009) and in healthy controls (23.5 (1.3-50.7), P0.0001). Serum ferritin levels in patients with NASH were also significantly higher than the levels in patients with simple steatosis. The receiver operating characteristic curve confirmed that serum TRX and ferritin levels were predictors for distinguishing NASH from simple steatosis. Higher grades of histological iron staining were observed in NASH than in simple steatosis. Serum TRX tended to increase in accordance with hepatic iron accumulation and the histological severity in patients with NASH.The pathogenesis of NASH may be associated with iron-related oxidative stress. The serum TRX level is a parameter for discriminating NASH from simple steatosis as well as a predictor of the severity of NASH. |
| Databáze: | OpenAIRE |
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