Antiviral potential of plant polysaccharide nanoparticles actuating non-specific immunity☆
| Autor: | Sergey V. Stovbun, Dmitry V. Zlenko, Aleksei V. Kiselev, Alexander A. Bukhvostov, Sergey V. Usachev, Tatiana S. Kalinina, Dmitry A. Kuznetsov, Alexander A. Litvin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Drug
Adult Male Adolescent Phagocytosis media_common.quotation_subject HL-60 Cells 02 engineering and technology Biology Pharmacology Polysaccharide Biochemistry Antiviral Agents Article Proinflammatory cytokine 03 medical and health sciences Structural Biology Auxin Polysaccharides Humans Secretion Antiviral activity Molecular Biology 030304 developmental biology media_common Immune modulator chemistry.chemical_classification 0303 health sciences Drug Carriers Innate immune system food and beverages COVID-19 General Medicine Plants 021001 nanoscience & nanotechnology COVID-19 Drug Treatment Probucol chemistry Nanoparticles 0210 nano-technology Drug carrier |
| Zdroj: | International Journal of Biological Macromolecules |
| ISSN: | 1879-0003 0141-8130 |
| Popis: | The development of high-end targeted drugs and vaccines against modern pandemic infections, such as COVID-19, can take a too long time that lets the epidemic spin up and harms society. However, the countermeasures must be applied against the infection in this period until the targeted drugs became available. In this regard, the non-specific, broad-spectrum anti-viral means could be considered as a compromise allowing overcoming the period of trial. One way to enhance the ability to resist the infection is to activate the nonspecific immunity using a suitable driving-up agent, such as plant polysaccharides, particularly our drug Panavir isolated from the potato shoots. Earlier, we have shown the noticeable anti-viral and anti-bacterial activity of Panavir. Here we demonstrate the pro-inflammation activity of Panavir, which four-to-eight times intensified the ATP and MIF secretion by HL-60 cells. This effect was mediated by the active phagocytosis of the Panavir particles by the cells. We hypothesized the physiological basis of the Panavir proinflammatory activity is mediated by the indol-containing compounds (auxins) present in Panavir and acting as a plant analog of serotonin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect