Amniotic Fluid Enhances Allogeneic Cytotoxic T Cell Responses, Whereas It Suppresses Mitogen-Stimulated Lymphocyte Proliferation
| Autor: | Izumi Nakashima, Yutaka Tomoda, Mahbuba Parvin, Ken-ichi Isobe, Heidari Zohreh, Setsuko Goto |
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| Rok vydání: | 1994 |
| Předmět: |
Lipopolysaccharides
Isoantigens Cellular immunity Amniotic fluid Immunology Lymphocyte proliferation Biology Lymphocyte Activation Microbiology Mice Antigen Pregnancy Virology Concanavalin A Animals Cytotoxic T cell Mice Inbred BALB C Mice Inbred C3H H-2 Antigens T lymphocyte Amniotic Fluid Mice Inbred C57BL Transplantation CTL Female Cell Division T-Lymphocytes Cytotoxic |
| Zdroj: | Microbiology and Immunology. 38:327-330 |
| ISSN: | 0385-5600 |
| DOI: | 10.1111/j.1348-0421.1994.tb01786.x |
| Popis: | Mouse amniotic fluid has been shown to suppress T lymphocyte proliferation and suggested to be important in regulating immunity during pregnancy. In allogeneic pregnancy, cytotoxic T cells in pregnant lymphocytes against paternal transplantation antigen are impaired. We examined the effect of amniotic fluid to the alloreactive CTL responses. Although the amniotic fluid suppressed Con A or LPS stimulated lymphocyte proliferation as previously reported, the amniotic fluid taken from syngeneic C57BL/6 pregnant mice or allogeneic C57BL/6 x BALB/c pregnant mice enhanced the anti-H-2d or anti-H-2k CTL responses dose-dependently. We speculate that amniotic fluid contains not only immunosuppressive factors but also immunoenhancing factors which upregulate the allogeneic CTL responses. |
| Databáze: | OpenAIRE |
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