Chikungunya outbreak in Delhi, India, 2016: report on coinfection status and comorbid conditions in patients
| Autor: | Navjot Kaur, D. Kumar, Ankit Kumar, M. Narang, Rajni Gaind, A. Marcello, M.K. Zakaria, Sujatha Sunil, Jaspreet Jain |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty viruses 030231 tropical medicine India Dengue virus medicine.disease_cause Microbiology Virus Dengue fever Zika virus Serology lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Internal medicine medicine lcsh:RC109-216 Chikungunya biology outbreak business.industry Outbreak virus diseases medicine.disease biology.organism_classification Virology 030104 developmental biology Infectious Diseases Coinfection Original Article business |
| Zdroj: | New Microbes and New Infections, Vol 20, Iss C, Pp 39-42 (2017) New Microbes and New Infections |
| ISSN: | 2052-2975 |
| Popis: | Chikungunya fever is a major public health issue in India affecting billions. After 2010, the infection was in a decline until in 2016, when a massive outbreak affected the country. In this report, we present serologic and molecular investigations of 600 patient samples for chikungunya and dengue viruses along with clinical and comorbidity features. We recruited 600 patients during this outbreak and evaluated them for chikungunya and dengue virus antibodies and virus RNA through IgM, NS1 antigen and quantitative real-time PCR (qPCR). We further evaluated Zika virus RNA by qPCR. Additionally, we documented all clinical and comorbid features that were observed during the outbreak in the hospital. We report a total incidence rate of 58% of chikungunya during the outbreak in our hospital. Within the recruited patients, 70% of the patients were positive for chikungunya virus IgM whereas 24.17% were positive by qPCR. None of the samples was positive for Zika virus RNA. Additionally, coinfection of dengue and chikungunya was seen in 25.33% of patients. Analysis of clinical features revealed that 97% of patients had restricted movements of the joints with other features like swelling, itching and rashes of varying severity observed. Twelve patients presented with comorbid conditions, and two fatalities occurred among these comorbid patients. The high incidence of coinfection in the current outbreak warrants implementation of routine testing of both chikungunya and dengue virus in suspected patients for better patient management. The post–acute phase complications reported in the hospitals require in-depth studies to understand the actual impact of the current outbreak. |
| Databáze: | OpenAIRE |
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