Haplotype-based case-control study of receptor (calcitonin) activity-modifying protein-1 gene in cerebral infarction
| Autor: | Masayoshi Soma, Tomohiro Nakayama, Takahiro Naganuma, T Nakazato, Zhaoxia Wang, Kaoru Sugama, Shigeaki Hinohara, Zhen-Yan Fu, Naoyuki Sato, Nobutaka Doba |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Genotype Single-nucleotide polymorphism Calcitonin gene-related peptide Polymorphism Single Nucleotide RAMP1 Gene Receptor Activity-Modifying Proteins Receptor Activity-Modifying Protein 1 Gene Frequency Japan Internal medicine Internal Medicine Medicine Humans Genetic Predisposition to Disease Allele frequency Aged business.industry Haplotype Intracellular Signaling Peptides and Proteins Membrane Proteins Cerebral Infarction Middle Aged Endocrinology Haplotypes Calcitonin RAMP1 Case-Control Studies Female business |
| Zdroj: | Journal of human hypertension. 24(5) |
| ISSN: | 1476-5527 |
| Popis: | Calcitonin gene-related peptide (CGRP) receptor is a complex molecule that consists of calcitonin receptor-like receptor and receptor activity-modifying protein-1 (RAMP1). It was recently reported that RAMP1-deficient mice (RAMP1(−/−)) showed inflammatory responses with a transiently significant increase in serum CGRP levels and proinflammatory cytokines when compared with RAMP1(+/+) mice. The aim of this study was to investigate the relationship between the human RAMP1 gene and cerebral infarction (CI) using single-nucleotide polymorphisms (SNPs) in a Japanese population. We selected six SNPs in the human RAMP1 gene (rs3754701, rs3769048, rs7557078, rs1584243, rs10199956 and rs7590387) and performed a case–control study using each SNP and haplotype in 171 CI patients and 234 controls. There were no significant differences in overall distribution of genotype and allele frequencies of the SNPs between the CI and control groups. However, there was a significant difference in overall distribution between the CI and control groups (P |
| Databáze: | OpenAIRE |
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