Leukotriene haplotype × diet interaction on carotid artery hypertrophy and atherosclerosis in American Indians: The Strong Heart Family Study
| Autor: | Shelley A. Cole, Lyle G. Best, Richard B. Devereux, Barbara V. Howard, Ying Zhang, Elisa T. Lee, Fawn Yeh, Jinying Zhao, Mary J. Roman, Karin Haack |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Carotid Artery Diseases Male medicine.medical_specialty Genotype Carotid arteries Biology Carotid Intima-Media Thickness Polymorphism Single Nucleotide Article Muscle hypertrophy Leukotriene-A4 hydrolase Fatty Acids Omega-6 Internal medicine Fatty Acids Omega-3 medicine Humans Epoxide Hydrolases chemistry.chemical_classification Leukotriene Dietary intake Haplotype Hypertrophy Middle Aged Dietary Fats Carotid Arteries Endocrinology Haplotypes chemistry Indians North American Female Cardiology and Cardiovascular Medicine Polyunsaturated fatty acid |
| Zdroj: | Atherosclerosis. 233:165-171 |
| ISSN: | 0021-9150 |
| Popis: | Abstarct Objective Gene × diet interaction plays an important role in atherosclerosis, an inflammatory disorder. Leukotrienes are the most potent inflammatory mediators, and genetic variants encoding leukotriene genes have been implicated in atherosclerosis. This study tests nutrigenetic interaction of a previously defined leukotriene haplotype on carotid artery hypertrophy and atherosclerosis in American Indians. Methods This study included 3402 American Indians participating in the Strong Heart Family Study (SHFS). Carotid artery measurements, including intima-media thickness (IMT), vascular mass, and plaque, were assessed using ultrasound. Eleven tagSNPs in the leukotriene A4 hydrolase ( LTA4H ) gene were genotyped in all subjects. Main haplotype effect and haplotype × diet interaction were examined by generalized estimating equation, adjusting for known risk factors. Results There was no significant main effect of haplotype or diet on any of the carotid artery measures. However, a previously defined LTA4H haplotype, called HapE, significantly interacted with dietary intake of n-3 and n-6 fatty acids on both IMT ( P HapE×n3 = 0.018, P HapE×n6 = 0.040) and vascular mass ( P HapE×n3 = 0.012, P HapE×n6 = 0.018), but not plaque. The direction of this nutrigenetic interaction on IMT was consistent with that reported in a recent study of Caucasian twins. Conclusion Dietary intake of polyunsaturated fatty acids significantly modifies the effect of a leukotriene haplotype on carotid artery hypertrophy but not atherosclerosis in American Indians, independent of established cardiovascular risk factors. Replication of nutrigenetic interaction in two distinct ethnic groups suggests the robustness and generalizability of our findings to diverse populations. |
| Databáze: | OpenAIRE |
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