THEORETICAL CONFORMATIONAL ANALYSIS OF METHYLAMIDES OF N-ACETYL-L-SERINE AND N-ACETYL-L-ASPARAGINE
| Autor: | E. M. Popov, Gregory M. Lipkind, S. F. Arkhipova |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Chemical Phenomena
Optical Rotation Spectrophotometry Infrared Molecular model Stereochemistry Molecular Conformation Peptide Carboxypeptidases L serine Biochemistry Ribonucleases Serine Side chain Chymotrypsin chemistry.chemical_classification Myoglobin Chemistry Hydrogen bond N-acetyl-L-asparagine Amides Models Structural Crystallography Lactalbumin Muramidase Asparagine Peptides |
| Zdroj: | International Journal of Peptide and Protein Research. 5:381-397 |
| ISSN: | 0367-8377 |
| Popis: | Theoretical analysis of conformations of methylamides of N-acetyl-L-serine and N-acetyl-L-asparagine was carried out proceeding from a mechanical molecular model. The important role of hydrogen bonds between the side chain and the backbone in stabilizing the most favourable forms was shown. An evaluation was made of the mobility of the side chain for different conformations of the backbone by calculating the statistical sums. Free energy was shown to have a minimum for the forms of the B type. The agreement between the results of calculating a model peptide and the conformational distribution of Asn and Ser residues in proteins is discussed. |
| Databáze: | OpenAIRE |
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