The response to prednisolone in atrophic gastritis: a possible effect on non-intrinsic factor-mediated vitamin B12 absorption
| Autor: | K.B. Taylor, R.G. Strickland, June M. Fisher, Klaus Lewin |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Intrinsic Factor
Male medicine.medical_specialty Atrophic gastritis Prednisolone Fluorescent Antibody Technique Antibodies Intestinal absorption Pernicious anaemia Internal medicine Anemia Pernicious medicine Gastric mucosa Humans Vitamin B12 Binding Sites Gastric Juice Intrinsic factor business.industry Stomach Complement Fixation Tests Gastroenterology Articles medicine.disease Cobalt Isotopes Vitamin B 12 medicine.anatomical_structure Endocrinology Intestinal Absorption Gastric Mucosa Gastritis Female business medicine.drug |
| Zdroj: | Gut. 14:13-19 |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.14.1.13 |
| Popis: | The administration of prednisolone did not affect absorption of vitamin B(12) and gastric secretion of intrinsic factor in nine subjects with normal gastric mucosa, or in five with chronic superficial gastritis. No gastric morphological changes were observed in either group. In contrast, four of seven patients with pernicious anaemia showed improvement in absorption of vitamin B(12) during prednisolone administration for periods of two to 10 months. No consistent changes in gastric mucosal morphology were noted. An additional five patients were studied intensively during one month of prednisolone administration. In three, absorption of vitamin B(12) was restored to within the normal range between eight and 13 days after the commencement of the drug. The improvement was not paralleled by enhancement of secretion of intrinsic factor or other vitamin B(12) binders. Suppression of intrinsic factor antibodies in serum and gastric juice did not occur consistently in those patients showing a functional response. |
| Databáze: | OpenAIRE |
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