Sequential expression of annexin A5 in the vasculature and skeletal elements during mouse development
| Autor: | K von der Mark, B Brachvogel, H Welzel, Clementine Hofmann, Ernst Pöschl, H Moch |
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| Rok vydání: | 2001 |
| Předmět: |
Embryology
Time Factors Cell In situ hybridization Biology Bone and Bones Mice Annexin Genes Reporter Notochord medicine Animals Cell Lineage Tissue Distribution RNA Messenger Annexin A5 In Situ Hybridization Reporter gene Models Genetic Cartilage Molecular biology Immunohistochemistry medicine.anatomical_structure Lac Operon Blood Vessels Annexin A2 Protein Binding Developmental Biology |
| Zdroj: | Mechanisms of Development. 109(2):389-393 |
| ISSN: | 0925-4773 |
| DOI: | 10.1016/s0925-4773(01)00532-9 |
| Popis: | Annexin A5 (annexin V, anchorin CII) represents the prototype member of the large annexin family, characterized by its ability to interact with phospholipids in a calcium-dependent manner and to form calcium-specific ion channels. Despite intense biochemical analysis, the in vivo expression and function of this annexin during mouse development, still remains unclear. Immunohistochemistry, in situ hybridization and reporter gene expression were used to define expression of annexin A5 during early mouse development. First, annexin A5 expression is associated with the developing vascular system. Later, expression is detected within the notochord and found in parallel to the differentiation of cartilage and bone. Therefore, expression of the Anxa5 gene may represent a novel marker characterizing cell lineages involved in the development of the vascular as well as the skeletal system. |
| Databáze: | OpenAIRE |
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