| Autor: |
Yuliya V. Perfilyeva, Yekaterina O. Ostapchuk, Raikhan Tleulieva, Aykin Kali, Nurshat Abdolla, Vladimir K. Krasnoshtanov, Anastassiya V. Perfilyeva, Nikolai N. Belyaev |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinical immunology (Orlando, Fla.). 238 |
| ISSN: |
1521-7035 |
| Popis: |
Coronavirus disease 2019 (COVID-19) is a potentially life-threatening infection characterized by excessive inflammation, coagulation disorders and organ damage. A dysregulated myeloid cell compartment is one of the most striking immunopathologic signatures of this newly emerged infection. A growing number of studies are reporting on the expansion of myeloid cells with immunoregulatory activities in the periphery and airways of COVID-19 patients. These cells share phenotypic and functional similarities with myeloid-derived suppressor cells (MDSCs), which were first described in cancer patients. MDSCs are a heterogeneous population of pathologically activated myeloid cells that exert immunosuppressive activities against mainly effector T cells. The increased frequency of these cells in COVID-19 patients suggests that they are involved in immune regulation during this infection. In this article, we review the current findings on MDSCs in COVID-19 and discuss the complex role of these cells in the immunopathology of COVID-19. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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