Multiple primary cancer: an experience at the Cancer Institute Hospital with special reference to colorectal cancer
| Autor: | Hirotoshi Ota, Toshiharu Yamaguchi, Tetsuichiro Muto, Kaoru Azekura, Masashi Ueno, Masatoshi Oya |
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| Rok vydání: | 2003 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Colorectal cancer Risk Assessment Neoplasms Multiple Primary Breast cancer Age Distribution Japan Surgical oncology Internal medicine Epidemiology of cancer medicine Humans Registries Sex Distribution Survival analysis Aged Neoplasm Staging Probability business.industry Incidence Cancer Hematology General Medicine Middle Aged medicine.disease Survival Analysis Cancer registry Surgery Female business Risk assessment Colorectal Neoplasms |
| Zdroj: | International journal of clinical oncology. 8(3) |
| ISSN: | 1341-9625 |
| Popis: | Cancer patients are at high risk of developing a second cancer after the treatment of initial cancers. Understanding the characteristics of multiple primary cancer is important to establish an effective surveillance program for the early detection of second cancers.We analyzed the cancer registry records from 1986 to 1995 at the Cancer Institute Hospital. The combination of the sites of the index and second cancers and the time intervals between the two cancers were examined. For colorectal cancer, another database of patients between 1946 and 1991 was analyzed, with special reference to synchronous and metachronous cancers.Out of 24,498 registered cases, there were 1281 (5.2%) multiple cancers, of which 464 (1.9%) were in the same organs and 817 (3.3%) were in other organs. Gastric or colorectal cancer frequently developed as the second cancer regardless of the site of the index cancer. Although the majority of the second cancers developed within 3 years after the index cancer, some developed 5 years or more after the index cancer. In colorectal cancer, the cases with metachronous cancer were similar to those with hereditary nonpolyposis colon cancer. The frequent combination of an advanced index cancer and an advanced second cancer and relatively poor survival after the second cancers in the metachronous cases may reflect delayed diagnosis of the second colorectal cancer.Careful attention should always be paid to the second cancer in treating cancer patients. Further analysis by individual site of the index cancers is needed to construct an effective surveillance for second cancers. |
| Databáze: | OpenAIRE |
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