Mortality and risk factors among Israeli bullous pemphigoid patients
| Autor: | Mati Rozenblat, Michael Ziv, Roni Dodiuk-Gad, Tal Rozenblat, Mohammad Sah, Shani Fisher, Awad Halaj |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Aging Pemphigoid medicine.medical_specialty Multivariate analysis Age at diagnosis Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Pemphigoid Bullous Humans Medicine Dementia Israel Risk factor Aged Retrospective Studies Aged 80 and over business.industry Mortality rate Matched control General Medicine Middle Aged medicine.disease Case-Control Studies 030220 oncology & carcinogenesis Female Bullous pemphigoid Hydroxymethylglutaryl-CoA Reductase Inhibitors business |
| Zdroj: | Archives of Dermatological Research. 311:19-27 |
| ISSN: | 1432-069X 0340-3696 |
| DOI: | 10.1007/s00403-018-1875-z |
| Popis: | There are differences concerning reported mortality rates and prognostic factors of bullous pemphigoid (BP) patients in different studies. Our objectives were to evaluate the mortality rates and prognostic factors among Israeli BP patients compared to matched control subjects. Three age- and sex-matched patients without BP (n = 261) who were treated in our clinic were selected and compared to BP patients (n = 87). Mean survival period of the BP group was 4.1 years (95% CI: 3.3-4.8 years) and 5.9 years among the non-BP group (95% CI: 5.6-6.3 years). The 1-year mortality rate was 24.1% for the BP group and 6.5% for the control group. In multivariate analysis, age above 80 was a significant risk factor for mortality [HR 3.22 (95% CI, 1.15-8.96), p = 0.03], while statins intake had a protective role [HR 0.36 (95% CI, 0.15-0.88), p = 0.03]. In univariant analysis, dementia [HR 2.44 (95% CI, 1.02-5.99), p = 0.04] was a risk factor. In conclusion, BP patients' mortality is correlated to increasing age at diagnosis, dementia, and statins use. Statins' protective role is newly discussed in the literature. |
| Databáze: | OpenAIRE |
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