Evolution of serum Anti-Müllerian Hormone (AMH) level in young women treated with chemotherapy for breast cancer according to basal AMH level
| Autor: | A. Dezellus, Paul Barrière, S Loubersac, Thomas Fréour, D. Masson, Tiphaine Lefebvre, Arnaud Reignier |
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| Přispěvatelé: | Centre hospitalier universitaire de Nantes (CHU Nantes), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Nantes Université (Nantes Univ), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Neuropathies du système nerveux entérique et pathologies digestives, implication des cellules gliales entériques, Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), CCSD, Accord Elsevier |
| Rok vydání: | 2020 |
| Předmět: |
Anti-Mullerian Hormone
endocrine system endocrine system diseases [SDV]Life Sciences [q-bio] medicine.medical_treatment Physiology Breast Neoplasms Reproductive age Anti-Müllerian hormone 03 medical and health sciences Basal (phylogenetics) Breast cancer 0302 clinical medicine Humans Medicine Prospective Studies 030212 general & internal medicine Fertility preservation Ovarian reserve Prospective cohort study Chemotherapy 030219 obstetrics & reproductive medicine biology urogenital system business.industry Reproduction Obstetrics and Gynecology medicine.disease female genital diseases and pregnancy complications [SDV] Life Sciences [q-bio] Reproductive Medicine biology.protein Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology European Journal of Obstetrics & Gynecology and Reproductive Biology, 2020, 254, pp.132-137. ⟨10.1016/j.ejogrb.2020.09.016⟩ European Journal of Obstetrics & Gynecology and Reproductive Biology, Elsevier, 2020, 254, pp.132-137. ⟨10.1016/j.ejogrb.2020.09.016⟩ |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2020.09.016 |
| Popis: | International audience; Objective: Serum AMH level has been shown to decrease in women treated for breast cancer in several studies. However, whether basal AMH status affects AMH dynamics during chemotherapy remains to be clarified. The objective of this study was to compare serum AMH dynamics in young women with either low, normal or high basal serum AMH level at diagnosis, during and after treatment with chemotherapy for breast cancer.Study design: In this secondary analysis of a prospective cohort study, serum AMH was measured during and after chemotherapy in 239 women of reproductive age diagnosed with breast cancer and treated with chemotherapy. The association between AMH dynamics throughout chemotherapy and during follow-up and basal AMH status, i.e. low AMH (36 pmol/l), was evaluated. Menses occurrence was also recorded.Results: A total of 21 women had low, 154 had normal and 64 had high basal AMH level. Serum AMH rapidly decreased during chemotherapy in all groups, and its variation during chemotherapy and follow-up was not significantly different between the 3 groups.Conclusion: No association was found between AMH variation during chemotherapy and follow-up, and basal AMH level at diagnosis. However, women with high basal AMH levels have significantly higher AMH levels throughout chemotherapy and follow-up than women with normal or low basal AMH levels at diagnosis. |
| Databáze: | OpenAIRE |
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