Blood rheology and albumin excretion in diabetic pregnancy
| Autor: | J. D. Quin, Gdo Lowe, D. S. J. O'reilly, C. B. Lunan, S. Pinion, S. M. Macrury, A. C. MacCuish |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism Pregnancy Trimester Third Blood viscosity Pregnancy in Diabetics Renal function Blood Pressure Hematocrit Endocrinology Pregnancy Reference Values Diabetes mellitus Internal medicine Internal Medicine Medicine Albuminuria Humans Prospective Studies medicine.diagnostic_test business.industry medicine.disease Blood Viscosity Pregnancy Trimester First Blood pressure Diabetes Mellitus Type 1 Regional Blood Flow Pregnancy Trimester Second Gestation Regression Analysis Female medicine.symptom business Rheology |
| Zdroj: | Diabetic medicine : a journal of the British Diabetic Association. 12(1) |
| ISSN: | 0742-3071 |
| Popis: | Blood rheology is altered in diabetes and also in non-diabetic pregnant women. The cumulative effect of hyperfiltration, abnormal rheology of pregnancy, and diabetes could be one mechanism contributing to increased intraglomerular pressure and albuminuria in diabetic pregnancy. We conducted a prospective study of 22 Type 1 (insulin-dependent) diabetic patients and 22 non-diabetic women to determine if there was an association of altered blood rheology on glomerular function in diabetic pregnancy. Albumin excretion showed no increment with increasing gestation and was similar in diabetic and non-diabetic women throughout pregnancy (first trimester: 5.0 (3.0-14.0) vs 5.8 (3.7-10.7) mg l-1, p = 0.89; second trimester: 6.0 (5.0-12.0) vs 5.1 (3.6-10.4) mg l-1, p = 0.25; third trimester: 7.5 (3.5-16.0) vs 4.9 (2.9-7.3) mg l-1, p = 0.18). Red cell aggregation index increased in both groups between the first and third trimesters (diabetic patients: mean difference 2.0; Cl: 1.0-2.9, p = 0.003, and control patients: mean difference 2.3, Cl: 1.0-3.5, p = 0.002). Fibrinogen levels were significantly higher between the third and first trimesters in diabetic patients (mean difference 0.7, Cl: 0.2-1.3 g l-1, p = 0.006). Pregnancy, therefore, was associated with increased red cell aggregation, related in part to increased fibrinogen levels but the extent of change was similar in diabetic and nondiabetic women and appeared to have no adverse effect on glomerular function in pregnant insulin-dependent diabetic women. |
| Databáze: | OpenAIRE |
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