Metathetic sulfur transfer mediated by N-(2-aminophenyl)-4-methyl-thiazolin-2-thione derivatives: a route to diversely substituted S-alkylcarbamothioates
| Autor: | Nicolas Vanthuyne, Federico Andreoli, Mohammed Amine Mehdid, Abdallah Larbi Doukara, Christian Roussel, Ayada Djafri |
|---|---|
| Přispěvatelé: | Institut des Sciences Moléculaires de Marseille (ISM2), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
chemistry.chemical_classification
Benzimidazole Base (chemistry) 010405 organic chemistry Organic Chemistry chemistry.chemical_element Alkylation 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry Chemical synthesis Sulfur Nitrogen 0104 chemical sciences chemistry.chemical_compound chemistry Drug Discovery Urea [CHIM]Chemical Sciences After treatment ComputingMilieux_MISCELLANEOUS |
| Zdroj: | Tetrahedron Tetrahedron, Elsevier, 2010, 66 (10), pp.1852-1858. ⟨10.1016/j.tet.2010.01.020⟩ Tetrahedron, 2010, 66 (10), pp.1852-1858. ⟨10.1016/j.tet.2010.01.020⟩ |
| ISSN: | 0040-4020 |
| Popis: | A new route to S-alkylcarbamothioates is disclosed. In a first step, N-(2-aminophenyl)-4-methyl-thiazolin-2-thione is transformed into a mono- or disubstituted urea at nitrogen, and then in a second step, alkylated at sulfur. The resulting salts, after treatment with a base, gave S-alkylcarbamothioates in high isolated yields together with 3-methyl[1,3]thiazolo[3,2-a]benzimidazole under very mild conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect