Pioglitazone-loaded nanostructured hybrid material for skin ulcer treatment
| Autor: | Szczepan Zapotoczny, Krzysztof Szczubiałka, Agnieszka Rojewska, Anna Karewicz, Karol Wolski, Mateusz Zając, Kamil Kamiński, Maria Nowakowska, Karolina Karnas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Hydrochloride
Nanoparticle bacterial nanocellulose wound healing 02 engineering and technology Polysaccharide lcsh:Technology Article Nanocellulose Chitosan 03 medical and health sciences chemistry.chemical_compound medicine alginate General Materials Science lcsh:Microscopy drug release lcsh:QC120-168.85 030304 developmental biology chemistry.chemical_classification 0303 health sciences integumentary system lcsh:QH201-278.5 lcsh:T Hydroxypropyl cellulose hydroxypropyl cellulose 021001 nanoscience & nanotechnology chemistry lcsh:TA1-2040 lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering pioglitazone hydrochloride lcsh:Engineering (General). Civil engineering (General) 0210 nano-technology Hybrid material lcsh:TK1-9971 Pioglitazone medicine.drug Nuclear chemistry |
| Zdroj: | Materials Materials, Vol 13, Iss 2050, p 2050 (2020) Volume 13 Issue 9 |
| Popis: | Pioglitazone, a popular antidiabetic drug, which was recently shown to be effective in the treatment of skin ulcers, was successfully encapsulated in polysaccharide nanoparticles and used as a bioactive component of the wound-dressing material based on modified bacterial nanocellulose. Alginate and hydroxypropyl cellulose were used as a matrix for the nanoparticulate drug-delivery system. The matrix composition and particles&rsquo size, as well as drug encapsulation efficiency and loading, were optimized. Pioglitazone hydrochloride (PIO) loaded particles were coated with chitosan introduced into the crosslinking medium, and covalently attached to the surface of bacterial nanocellulose functionalized with carboxyl groups. PIO was released from the surface of the hybrid material in a controlled manner for 5 days. Preliminary cytotoxicity studies confirmed safety of the system at PIO concentrations as high as 20 mg/mL. The obtained hybrid system may have potential application in the treatment of skin ulcers e.g., in diabetic foot. |
| Databáze: | OpenAIRE |
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