Modulation of latent inhibition in the rat by altered dopamine transmission in the nucleus accumbens at the time of conditioning
| Autor: | M.H. Joseph, S.L. Peters, Paula M. Moran, Andrew M. J. Young, G. A. Grigor'yan, J.A. Gray |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Dopamine Nucleus accumbens Synaptic Transmission Nucleus Accumbens Injections Rats Sprague-Dawley Latent inhibition Dopamine Uptake Inhibitors Internal medicine Conditioning Psychological Reaction Time medicine Animals Oxidopamine Amphetamine Prepulse inhibition Brain Diseases Behavior Animal General Neuroscience Dopamine antagonist Association Learning Neural Inhibition Rats Ventral tegmental area medicine.anatomical_structure Endocrinology Dopamine Antagonists Haloperidol Psychology Neuroscience Injections Intraperitoneal medicine.drug |
| Zdroj: | Neuroscience. 101:921-930 |
| ISSN: | 0306-4522 |
| Popis: | Latent inhibition describes a process by which pre-exposure of a stimulus without consequence retards the learning of subsequent conditioned associations with that stimulus. It is well established that latent inhibition in rats is impaired by increased dopamine function and potentiated by reduced dopamine function. Previous evidence has suggested that these effects are modulated via the meso-accumbens dopamine projections. We have now undertaken three experiments to examine this issue directly, especially in the light of one study in which latent inhibition was reported to be unaffected by direct injection of amphetamine into the accumbens. Latent inhibition was studied using the effect of pre-exposure of a tone stimulus on the subsequent formation of a conditioned emotional response to the tone. 6-Hydroxydopamine-induced lesions of dopamine terminals in the nucleus accumbens resulted in potentiation of latent inhibition. Bilateral local injections of the dopamine antagonist haloperidol into the nucleus accumbens (0.5 microg/side) before conditioning also potentiated latent inhibition. Moreover, such injections were able to reverse the disruptive effect of systemic amphetamine (1mg/kg, i.p.) on latent inhibition. Bilateral local injection of amphetamine (5 microg/side) into the nucleus accumbens before conditioning was able to disrupt latent inhibition, provided that it was preceded by a systemic injection of amphetamine (1mg/kg) 24h earlier.We conclude that the attenuation of latent inhibition by increased dopamine function in the nucleus accumbens is brought about by impulse-dependent release of the neurotransmitter occurring at the time of conditioning. The previously reported failure to disrupt latent inhibition with intra-accumbens amphetamine is probably due to impulse-independent release of dopamine. The implications of these conclusions for theories linking disrupted latent inhibition to the attentional deficits in schizophrenia, and to the dopamine theory of this disorder, are discussed. |
| Databáze: | OpenAIRE |
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