Air pollution and hippocampal atrophy in first episode schizophrenia
| Autor: | Donald C. Goff, Jijun Wang, Botao Zeng, Daphne J. Holt, Oliver Freudenreich, Michelle A. Worthington, Iruma Bello, Renrong Wu, Yingying Tang, Eva Petkova, Babak A. Ardekani, Xiaoduo Fan, Erica D. Diminich, Jingping Zhao, Corrine Cather |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
China
medicine.medical_treatment Physiology Hippocampal formation Citalopram medicine.disease_cause Hippocampus 03 medical and health sciences 0302 clinical medicine Atrophy Air Pollution medicine Humans Cities Antipsychotic Biological Psychiatry First episode business.industry medicine.disease 030227 psychiatry Psychiatry and Mental health Schizophrenia Biomarker (medicine) business 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Schizophrenia Research. 218:63-69 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2020.03.001 |
| Popis: | Air pollution has recently been linked to central nervous system (CNS) diseases, possibly mediated by inflammation and oxidative stress. Hippocampal atrophy in individuals with first episode schizophrenia (FES) has also been associated with biomarkers of inflammation and oxidative stress, whereas hippocampal atrophy was not observed in matched healthy controls with similar biomarker levels of inflammation and oxidative stress. Fine particulate matter (PM2.5), one component of air pollution, is most strongly implicated in CNS disease. The present study examined the association between PM2.5 and hippocampal volume in individuals with FES who participated in a 52-week placebo-controlled clinical trial of citalopram added to clinician-determined antipsychotic treatment at four sites in the US and China. Left hippocampal volumetric integrity (LHVI; inversely related to atrophy) was measured at baseline and week 52 using an automated highly-reliable algorithm. Mean annual PM2.5 concentrations were obtained from records compiled by the World Health Organization. The relationships between baseline LHVI and PM2.5 and change in LHVI and PM2.5 were evaluated using regression analyses. 89 participants completed imaging at baseline and 46 participants completed imaging at week 52. Mean annual PM2.5 was significantly associated with both baseline LHVI and change in LHVI after controlling for age, sex, baseline LHVI, duration of untreated psychosis and baseline antipsychotic medication dose. Air pollution may contribute to the progression of hippocampal atrophy after a first episode of illness, but these findings should be considered preliminary since other unmeasured factors may have differed between cities and contributed to the observed effect. |
| Databáze: | OpenAIRE |
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