Zebrafish Tmem230a cooperates with the Delta/Notch signaling pathway to modulate endothelial cell number in angiogenic vessels

Autor: Franco Cotelli, Rolland Reinbold, Lorenzo Sangiorgio, Gianluca Deflorian, Paride Pelucchi, Alberto Albertini, Antonio Giordano, Ileana Zucchi, James Kehler, Alessandra Mezzelani, Gianfranco Bellipanni, Silvia Carra, Mira Palizban, Solei Cermenati, Martin Götte, Valentina Martino, Monica Beltrame
Rok vydání: 2017
Předmět:
0301 basic medicine
Notch
Physiology
Angiogenesis
blood vessel formation growth
Clinical Biochemistry
Notch signaling pathway
Regulator
Neovascularization
Physiologic
Genetically Modified
Biology
Regenerative medicine
transmembrane protein 230
Animals
Genetically Modified
angiogenesis
03 medical and health sciences
Receptors
Vegf signaling
Animals
Developmental
Amino Acid Sequence
Physiologic
Zebrafish
Delta/Notch signaling
Base Sequence
Conserved Sequence
Endothelial Cells
Gene Expression Regulation
Developmental
Intracellular Signaling Peptides and Proteins
Membrane Proteins
Receptors
Notch
Signal Transduction
Zebrafish Proteins
Cell Proliferation
Cell Biology
Neovascularization
Cell growth
biology.organism_classification
Cell biology
Endothelial stem cell
030104 developmental biology
Gene Expression Regulation
Immunology
Signal transduction
Zdroj: Journal of cellular physiology
(2017): 1455–1467. doi:10.1002/jcp.26032
info:cnr-pdr/source/autori:Carra S.; Sangiorgio L.; Pelucchi P.; Cermenati S.; Mezzelani A.; Martino V.; Palizban M.; Albertini A.; Götte M.; Kehler J.; Deflorian G.; Beltrame M.; Giordano A.; Reinbold R.; Cotelli F.; Bellipanni G.; Zucchi I./titolo:Zebrafish Tmem230a cooperates with the Delta%2FNotch signaling pathway to modulate endothelial cell number in angiogenic vessels/doi:10.1002%2Fjcp.26032/rivista:Journal of cellular physiology (Print)/anno:2017/pagina_da:1455/pagina_a:1467/intervallo_pagine:1455–1467/volume
ISSN: 1097-4652
0021-9541
DOI: 10.1002/jcp.26032
Popis: During embryonic development, new arteries and veins form from preexisting vessels in response to specific angiogenic signals. Angiogenic signaling is complex since not all endothelial cells exposed to angiogenic signals respond equally. Some cells will be selected to become tip cells and acquire migration and proliferation capacity necessary for vessel growth while others, the stalk cells become trailer cells that stay connected with pre-existing vessels and act as a linkage to new forming vessels. Additionally, stalk and tip cells have the capacity to interchange their roles. Stalk and tip cellular responses are mediated in part by the interactions of components of the Delta/Notch and Vegf signaling pathways. We have identified in zebrafish, that the transmembrane protein Tmem230a is a novel regulator of angiogenesis by its capacity to regulate the number of the endothelial cells in intersegmental vessels by co-operating with the Delta/Notch signaling pathway. Modulation of Tmem230a expression by itself is sufficient to rescue improper number of endothelial cells induced by aberrant expression or inhibition of the activity of genes associated with the Dll4/Notch pathway in zebrafish. Therefore, Tmem230a may have a modulatory role in vessel-network formation and growth. As the Tmem230 sequence is conserved in human, Tmem230 may represent a promising novel target for drug discovery and for disease therapy and regenerative medicine in promoting or restricting angiogenesis. This article is protected by copyright. All rights reserved
Databáze: OpenAIRE
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