Combined iodine-125 plaque irradiation and indirect ophthalmoscope laser therapy of choroidal malignant melanomas: Comparison with iodine-125 and cobalt-60 plaque radiotherapy alone
| Autor: | Donald Mullen, James J. Augsburger, Markus Kleineidam |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Fundus Oculi medicine.medical_treatment Eye disease Brachytherapy law.invention Iodine Radioisotopes Lesion Cellular and Molecular Neuroscience law medicine Humans Cobalt Radioisotopes Fluorescein Angiography Melanoma Aged Ultrasonography Aged 80 and over medicine.diagnostic_test business.industry Plaque radiotherapy Choroid Neoplasms Middle Aged Prognosis medicine.disease Laser Fluorescein angiography Combined Modality Therapy Sensory Systems Surgery Ophthalmoscopy Radiation therapy Ophthalmology medicine.anatomical_structure Female Laser Therapy Choroid medicine.symptom business Nuclear medicine |
| Zdroj: | Graefe's Archive for Clinical and Experimental Ophthalmology. 231:500-507 |
| ISSN: | 1435-702X 0721-832X |
| Popis: | The authors studied the short-term impact of combined episcleral iodine-125 plaque radiotherapy and argon laser treatment in a series of 24 patients with choroidal malignant melanoma. All patients underwent plaque therapy prior to their initial laser session. All laser treatments were performed with an indirect ophthalmoscope argon green laser, using low-power, long-duration exposures. The endpoint of laser therapy was a well-defined atrophic circumbasal chorioretinal laser scar and complete or nearly complete nonfluorescence of the lesion on fluorescein angiography. In a case-by-case matched comparison study, the authors evaluated the relative local regression of tumors treated by combined plaque-laser therapy, iodine-125 plaque therapy alone, and cobalt-60 plaque therapy alone. The tumors treated with supplemental laser regressed substantially faster and more completely than did those treated by either type of plaque therapy alone. However, the short-term visual loss was greater in eyes treated by the combined therapy. |
| Databáze: | OpenAIRE |
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