Future applications: gene therapy
| Autor: | John Forsayeth, Krystof S. Bankiewicz, R.M. Richardson, Vanja Varenika |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Traumatic brain injury Genetic enhancement Genetic Vectors Neurosurgery Bioinformatics Article Viral vector Dependovirus Monitoring Intraoperative Medicine Animals Humans Stroke Brain Diseases business.industry General Medicine Genetic Therapy medicine.disease Magnetic Resonance Imaging Clinical trial Surgery Neurology (clinical) business Convection-Enhanced Delivery |
| Zdroj: | Neurosurgery clinics of North America. 20(2) |
| ISSN: | 1558-1349 |
| Popis: | Gene therapy for brain disorders is one of the most promising frontiers in the practice of restorative neurosurgery. There are significant experimental gene therapy initiatives underway that have led to currently active clinical trials using direct intracerebral delivery of viral vectors, and these treatments have been reported as safe and well tolerated. In the future, other clinical trials will likely use viral vectors to transfer genes that bestow on recipient tissue a desired enzymatic or neurotrophic activity relevant to the treatment of other neurodegenerative diseases, stroke, and traumatic brain injury. |
| Databáze: | OpenAIRE |
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