Micro-CT evaluation of asymmetrical ovine intervertebral disc height loss from surgical approach
| Autor: | Stefan Schwan, Felix Goehre, Christopher Ludtka, Andrea Friedmann, Ingo Wiesner, Walther Brehm |
|---|---|
| Přispěvatelé: | Department of Neurosciences, Clinicum, University of Helsinki, Neurokirurgian yksikkö, HUS Neurocenter, Publica |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
LUMBAR SPINE
0206 medical engineering 02 engineering and technology Intervertebral Disc Degeneration Intervertebral disc height 3124 Neurology and psychiatry 03 medical and health sciences lCT 0302 clinical medicine Animal model Imaging Three-Dimensional Characterization methods Medicine Animals Orthopedics and Sports Medicine Micro ct Intervertebral Disc Disc herniation Orthodontics Micro-computed tomography Surgical approach Sheep business.industry 3112 Neurosciences Intervertebral disc Anatomy X-Ray Microtomography DEGENERATION Height loss 3126 Surgery anesthesiology intensive care radiology 020601 biomedical engineering IVD degeneration Disc height MODEL Disease Models Animal medicine.anatomical_structure Disc degeneration VOLUME Surgery Female SHAPE business STEM-CELLS 030217 neurology & neurosurgery |
| Popis: | Purpose The primary goal of this study is to clearly define and evaluate new intervertebral disc height parameters in analysing the morphological pathology of disc degeneration for application in damage model and regeneration therapy development, as well as applying traditional variables to 3-D characterization methods. Methods A posterolateral surgical approach was used to induce disc degeneration in an ovine model. At 12-months post-operation, sheep vertebral segments were removed and characterized using micro-CT to evaluate disc height parameters in regard to injury localization. Results Statistically significant differences between the disc height loss of the left and right side of the disc, consistent with the lateral surgical approach used were seen using the modified average disc height method by Dabbs et al. However, convexity index and the newly proposed Cross Tilt Index did not conclusively demonstrate a difference. Conclusion Two-dimensional morphological evaluations can be applied in 3-D to provide a more complete picture of disc height loss for injury models. New 3-D parameters that are tailored to the type of surgical approach used should be investigated, with the 9-point system described herein providing a useful basis for derived values. Additionally, the surgical approach chosen when artificially injuring the disc can result in asymmetrical degeneration, as indicated by uneven disc height loss. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|