Combination Effect of δ-Tocotrienol and γ-Tocopherol on Prostate Cancer Cell Growth
| Autor: | Chiaki Sato, Tomohiro Yano, Nantiga Virgona, Saki Kaneko, Ayami Sato, Kozue Namiki |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
G2 Phase Male Cell cycle checkpoint Cell Survival medicine.medical_treatment Medicine (miscellaneous) Apoptosis Cell cycle phase 03 medical and health sciences chemistry.chemical_compound Prostate cancer 0302 clinical medicine Cell Line Tumor LNCaP medicine Anticarcinogenic Agents Humans Vitamin E Tocopherol Chromans Cell Proliferation Nutrition and Dietetics Plant Extracts Osmolar Concentration G1 Phase Cancer Bixaceae Prostatic Neoplasms medicine.disease Antineoplastic Agents Phytogenic Carotenoids Prostatic Neoplasms Castration-Resistant 030104 developmental biology chemistry 030220 oncology & carcinogenesis Cancer research Tocotrienol |
| Zdroj: | Journal of nutritional science and vitaminology. 63(5) |
| ISSN: | 1881-7742 |
| Popis: | Tocotrienols (T3s) and tocopherols (Tocs) are both members of the vitamin E family. It is known that δ-tocotrienol (δ-T3) has displayed the most potent anti-cancer activity amongst the tocotrienols. On the other hand, γ-tocopherol (γ-Toc) is reported to have a protective effect against prostate cancer. Therefore, we investigated whether the combination of γ-Toc and δ-T3 could strengthen the inhibitory effect of δ-T3 on prostate cancer cell growth. In this study the effect of combined δ-T3 (annatto T3 oil) and γ-Toc (Tmix, γ-Toc-rich oil) therapy was assessed against human androgen-dependent prostate cancer cells (LNCaP). We found that combined treatment of δ-T3 (10 μM) and γ-Toc (5 μM) resulted in reinforced anti-prostate cancer activity. Specifically, cell cycle phase distribution analysis revealed that in addition to G1 arrest caused by the treatment with δ-T3, the combination of δ-T3 with γ-Toc induced G2/M arrest. Enhanced induction of apoptosis by the combined treatment was also observed. These findings indicate that combination of δ-T3 and γ-Toc significantly inhibits prostate cancer cell growth due to the simultaneous cell cycle arrest in the G1 phase and G2/M phase. |
| Databáze: | OpenAIRE |
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