Current insights toward kidney injury: Decrypting the dual role and mechanism involved of herbal drugs in inducing kidney injury and its treatment
| Autor: | Ramarao Poduri, Gaurav Joshi, Shikha Thakur, T.P. Sri Laasya |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
lcsh:Biotechnology media_common.quotation_subject Ischemia Renal function Pharmacology Nephrotoxicity lcsh:TP248.13-248.65 Detoxification Nephroprotective agents medicine Herbal drugs media_common Kidney urogenital system business.industry medicine.disease Herbal drug development medicine.anatomical_structure Renal physiology Kidney injury Toxicity Nutraceuticals business Biotechnology |
| Zdroj: | Current Research in Biotechnology, Vol 2, Iss, Pp 161-175 (2020) |
| ISSN: | 2590-2628 |
| Popis: | The kidney is essential for the physiological functions of the body. When exposed to high concentrations of toxins, these may induce the toxicity of the kidney (kidney injury), leading to renal failure and precipitating a condition called nephrotoxicity. The toxicity may result from hemodynamic changes and directly harm the cells and tissue, and causes obstruction of renal excretion. Nephrotoxicity can also be induced by renal impairment leads to kidney-specific detoxification and diminished kidney function by ischemia and toxicants/drugs. Considering the possible damage to kidneys by drugs, patients are using the naturally derived substance, including herbal drugs or nutraceuticals. However, the safety concerns of herbal drugs and formulation in inducing kidney injury are an area of research. The present review is a concerted effort to assemble information mainly focusing on the kidney injury, its comprehensive categorization, i.e., mechanism of interaction of various enzyme systems of kidneys with drugs of herbal and synthetic origin and their outcomes. Moreover, the review also put forth the details of herbal drug that precipitate kidney injury and ameliorate it. The review is being put forward with an incentive to provide researchers with a comprehensive and updated literature on kidney injury by drugs of natural and synthetic origin and their molecular targets in the kidney. |
| Databáze: | OpenAIRE |
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