Is Glycemic Control Modulating Endoplasmic Reticulum Stress in Leukocytes of Type 2 Diabetic Patients?
| Autor: | Nadezda Apostolova, Celia Bañuls, Susana Rovira-Llopis, Victor M. Victor, Antonio Hernández-Mijares, Carlos Morillas, Milagros Rocha |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty endocrine system diseases Physiology Clinical Biochemistry Type 2 diabetes Oxidative and endoplasmic reticulum (ER) stress Endoplasmic Reticulum Biochemistry chemistry.chemical_compound Glycemic control Leukocyte-endothelial interactions Internal medicine Diabetes mellitus Leukocytes medicine Humans Type 2 diabetes (T2D) Endoplasmic Reticulum Chaperone BiP Molecular Biology General Environmental Science Glycemic chemistry.chemical_classification Reactive oxygen species business.industry Endoplasmic reticulum nutritional and metabolic diseases Cell Biology Middle Aged Endoplasmic Reticulum Stress medicine.disease Oxygen Endocrinology Diabetes Mellitus Type 2 chemistry General Earth and Planetary Sciences Female Tumor necrosis factor alpha Glycated hemoglobin business Dyslipidemia |
| Zdroj: | ANTIOXIDANTS & REDOX SIGNALING r-FISABIO. Repositorio Institucional de Producción Científica instname r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| ISSN: | 1523-0864 |
| Popis: | Oxidative and endoplasmic reticulum (ER) stress is related to type 2 diabetes (T2D), but the influence of glycemic control on these parameters and its relationship with leukocyte-endothelial interactions is not known. In our study population consisting of 164 diabetic patients, (102 with glycated hemoglobin [HbA1c] 7%) and 84 nondiabetic controls, we have verified a common anthropometric and metabolic pattern of T2D with dyslipidemia. Inflammatory parameters (high-sensitive C-reactive protein [hs-CRP] and tumor necrosis factor alpha [TNF alpha]) and E-selectin levels were enhanced in the HbA1c >7% group with regard to controls. O-2 consumption and mitochondrial membrane potential were lower in diabetic patients than in controls. Reactive oxygen species (ROS) production was enhanced in diabetic patients than in controls and positively correlated with HbA1c levels. GRP78 levels were higher in both diabetic groups. However, HbA1c (sXBP1), whereas HbA1c >7% patients exhibited preferentially enhanced levels of CHOP (CCAAT/enhancer binding protein [C/EBP] homologous protein) and activating transcription factor 6 (ATF6). Reduced leukocyte rolling velocity and increased rolling flux and adhesion were observed in diabetic patients. Our findings lead to the hypothesis of an association between poor glycemic control in T2D and increased leukocyte ROS production and chronic ER stress that could finally promote leukocyte-endothelial interactions, which, in turn, poses a risk of vascular complications for these patients. Antioxid. Redox Signal. 21, 1759-1765. |
| Databáze: | OpenAIRE |
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