An update on genomic-guided therapies for pediatric solid tumors
| Autor: | Laura Ren Huey Ip, Wenying Piao, Zoey Wing Yee Liu, Vivian Wai Yan Lui, Alan K. S. Chiang, Pui Chi Tsui, Yin-Fai Lee |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Genomics Antineoplastic Agents Bioinformatics 03 medical and health sciences 0302 clinical medicine Neoplasms Exome Sequencing Medicine Humans Exome Molecular Targeted Therapy Precision Medicine Child Exome sequencing Response Evaluation Criteria in Solid Tumors business.industry Cancer General Medicine Genome project Sequence Analysis DNA Precision medicine medicine.disease Pediatric cancer 030104 developmental biology Oncology 030220 oncology & carcinogenesis Mutation business |
| Zdroj: | Future oncology (London, England). 13(15) |
| ISSN: | 1744-8301 |
| Popis: | Currently, out of the 82 US FDA-approved targeted therapies for adult cancer treatments, only three are approved for use in children irrespective of their genomic status. Apart from leukemia, only a handful of genomic-based trials involving children with solid tumors are ongoing. Emerging genomic data for pediatric solid tumors may facilitate the development of precision medicine in pediatric patients. Here, we provide an up-to-date review of all reported genomic aberrations in the eight most common pediatric solid tumors with whole-exome sequencing or whole-genome sequencing data (from cBioPortal database, Pediatric Cancer Genome Project, Therapeutically Applicable Research to Generate Effective Treatments) and additional non-whole-exome sequencing studies. Potential druggable events are highlighted and discussed so as to facilitate preclinical and clinical research in this area. |
| Databáze: | OpenAIRE |
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