Fetal fibronectin testing in patients with short cervix in the midtrimester: can it identify optimal candidates for ultrasound-indicated cerclage?
| Autor: | Orion A. Rust, Martin Feuerman, Daniel G. Kiefer, Jaclyn Coletta, Sean M. Keeler, Ashley S. Roman |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Cervix Uteri law.invention Uterine Cervical Diseases Fetus Randomized controlled trial Pregnancy law medicine Humans Cerclage Cervical Ultrasonography Gynecology Fetal fibronectin Obstetrics business.industry Pregnancy Outcome Obstetrics and Gynecology medicine.disease Fibronectins Pregnancy Complications medicine.anatomical_structure Premature birth Pregnancy Trimester Second Vagina Premature Birth Gestation Female business |
| Zdroj: | American Journal of Obstetrics and Gynecology. 200:158.e1-158.e6 |
| ISSN: | 0002-9378 |
| Popis: | Objective The objective of the study was to determine the relationship between fetal fibronectin (fFN) testing prior to ultrasound-indicated cerclage and obstetric outcome. Study Design Singleton pregnancies between 18 and 24 weeks' gestation with an ultrasound-diagnosed short cervix ( 25%) of the chorioamniotic membranes into the endocervical canal were analyzed. The fFN testing was performed and patients were randomized to cerclage or no-cerclage. Groups were stratified by fFN result. Cerclage patients were compared with no-cerclage patients. The primary outcome was delivery prior to 35 weeks' gestation. Results Spontaneous preterm birth prior to 35 weeks' gestation occurred in 15 (44.1%) fFN-positive-cerclage patients and 16 (55.2%) fFN-positive no-cerclage patients ( P = .45). Similarly, it occurred in 16 (17.8%) fFN-negative cerclage patients and 11 (17%) fFN-no-cerclage patients ( P = .99). Conclusion fFN did not identify optimal candidates for cerclage. However, fFN testing before an ultrasound-indicated cerclage aids in counseling patients, anticipating the outcome of pregnancies complicated by cervical shortening. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect