Signaling Networks in Epithelial Tube Formation
| Autor: | Fernando Martín-Belmonte, Mariam Hachimi, Ilenia Bernascone |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Neural Tube Cell division Xenopus Cellular differentiation Morphogenesis Mitosis Biology Epithelial tube formation Epithelium General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences Dogs Imaging Three-Dimensional Cell Movement Cell polarity medicine Animals Humans Zebrafish Cell Proliferation Mice Knockout Regeneration (biology) Neural tube Cell Polarity Cell Differentiation Epithelial Cells Cell biology Wnt Proteins 030104 developmental biology medicine.anatomical_structure PERSPECTIVES Drosophila Signal transduction Signal Transduction |
| Zdroj: | Cold Spring Harbor Perspectives in Biology. 9:a027946 |
| ISSN: | 1943-0264 |
| DOI: | 10.1101/cshperspect.a027946 |
| Popis: | Epithelial tubes are crucial to the function of organ systems including the excretory, gastrointestinal, cardiovascular, and pulmonary. Studies in the last two decades using in vitro organotypic systems and a variety of animal models have substantiated a large number of the morphogenetic mechanisms required to form epithelial tubes in development and regeneration. Many of these mechanisms modulate the differentiation and proliferation events necessary for generating the cell movements and changes in cell shape to delineate the wide variety of epithelial tube sizes, lengths, and conformations. For instance, when coupled with oriented cell division, proliferation itself plays a role in changes in tube shape and their directed expansion. Most of these processes are regulated in response to signaling inputs from adjacent cells or soluble factors from the environment. Despite the great deal of recent investigation in this direction, the knowledge we have about the signaling pathways associated with all epithelial tubulogenesis in development and regeneration is still very limited. |
| Databáze: | OpenAIRE |
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