Relationship Between Insulin Sensitivity and Menstrual Cycle Is Modified by BMI, Fitness, and Physical Activity in NHANES

Autor: MacGregor, Kirstin A, Gallagher, Iain J, Moran, Colin N
Rok vydání: 2021
Předmět:
Adult
0301 basic medicine
Periodicity
insulin
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
media_common.quotation_subject
medicine.medical_treatment
Clinical Biochemistry
Adipose tissue
030209 endocrinology & metabolism
Context (language use)
Biochemistry
menstrual cycle
Body Mass Index
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Insulin resistance
Internal medicine
medicine
Humans
insulin sensitivity
NHANES
triglyceride
glucose
Exercise
Clinical Research Articles
Menstrual cycle
media_common
Triglyceride
business.industry
Insulin
Biochemistry (medical)
Cardiorespiratory fitness
Nutrition Surveys
medicine.disease
Cross-Sectional Studies
030104 developmental biology
chemistry
Physical Fitness
Female
Insulin Resistance
business
Body mass index
AcademicSubjects/MED00250
Zdroj: The Journal of Clinical Endocrinology and Metabolism
ISSN: 1945-7197
0021-972X
Popis: Context There is evidence demonstrating variation in insulin sensitivity across the menstrual cycle. However, to date, research has yielded inconsistent results. Objective This study investigated variation in insulin sensitivity across the menstrual cycle and associations with body mass index (BMI), physical activity, and cardiorespiratory fitness (CRF). Methods Data from 1906 premenopausal women in NHANES cycles 1999 to 2006 were analyzed. Menstrual cycle day was assessed using questionnaire responses recording days since last period. Rhythmic variation of plasma glucose, triglycerides, and insulin, homeostatic model of insulin resistance (HOMA-IR), and adipose tissue insulin resistance index (ADIPO-IR) across the menstrual cycle were analyzed using cosinor rhythmometry. Participants were assigned low or high categories of BMI, physical activity, and CRF, and category membership included in cosinor models as covariates. Results Rhythmicity was demonstrated by a significant cosine fit for glucose (P = .014) but not triglycerides (P = .369), insulin (P = .470), HOMA-IR (P = .461), and ADIPO-IR (P = .335). When covariates were included, rhythmicity was observed when adjusting for: 1) BMI: glucose (P Conclusion Rhythmicity in insulin sensitivity and associated metabolites across the menstrual cycle are modified by BMI, physical activity, and CRF.
Databáze: OpenAIRE
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