The relationship between cytotoxin-associated gene A positiveHelicobacter pyloriinfection and autoimmune thyroid disease
| Autor: | Basak Karbek, Oya Topaloglu, Osman Yüksel, Esra Tutal, Tuncay Delibasi, Fuat Ekiz, Muyesser Sayki Arslan, Mustafa Sahin, Mustafa Ozbek, Erman Cakal, Zeynep Ginis, Murat Deveci |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Thyroid Gland Hashimoto Disease Thyroid Function Tests Thyroid function tests Gastroenterology Thyroiditis Helicobacter Infections Endocrinology Bacterial Proteins Risk Factors Internal medicine medicine Humans CagA Helicobacter Dyspepsia Prospective cohort study Ultrasonography Breath test Antigens Bacterial Helicobacter pylori medicine.diagnostic_test biology business.industry Thyroid General Medicine Middle Aged bacterial infections and mycoses medicine.disease biology.organism_classification medicine.anatomical_structure Female business |
| Zdroj: | Endocrine Research. 40:211-214 |
| ISSN: | 1532-4206 0743-5800 |
| DOI: | 10.3109/07435800.2015.1015727 |
| Popis: | The aim of this study was to determine whether there is an association between cagA [cytotoxin-associated gene A] positivity and thyroid autoimmunity and thyroid volume.This prospective study included 78 Helicobacter pylori-positive (H. pylori) dyspeptic patients in the study group, and 50 age-, gender-, and body mass index-matched H. pylori-negative dyspeptic patients in the control group. All the controls were evaluated via upper gastrointestinal endoscopic biopsy or breath test, and were found as H. pylori negative. Gastric biopsy specimens were obtained via endoscopy and histological examination was performed for documentation of H. pylori.In all, 55.1% (n = 43) of the H. pylori-positive patients were cagA positive. There was no significant difference in metabolic syndrome parameters or thyroid function test results between the study and control groups. The frequency of anti-TPO and Hashimoto's thyroiditis positivity was significantly higher in the study group than in the control group. Thyroid volume was higher and severe parenchymal heterogeneity was more common in the H. pylori-positive patients.H. pylori infection might be a risk factor for autoimmune thyroid disease and high thyroid volume in patients diagnosed with histological evaluation. However, cagA positivity has no additional effect on these parameters. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |