Development of Hypoxemia in Alcoholic Liver Disease
| Autor: | Akihide Udagawa, Satoru Yamamoto, Masaharu Koda, Chisato Hirayama, Kazunori Maeda, Kensuke Umeki, Shigeo Maruyama, Masayuki Inoue |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Liver Cirrhosis Male Alcoholic liver disease medicine.medical_specialty Cirrhosis Alcohol Drinking Physiology media_common.quotation_subject chemistry.chemical_element Alcohol Oxygen Gastroenterology Hepatitis Hypoxemia chemistry.chemical_compound Oxygen Consumption Liver Function Tests Disease severity Internal medicine Humans Medicine Hypoxia Liver Diseases Alcoholic Aged media_common business.industry Middle Aged Hepatology Abstinence medicine.disease Surgery chemistry Multivariate Analysis Female medicine.symptom business Fatty Liver Alcoholic |
| Zdroj: | Digestive Diseases and Sciences. 50:290-296 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/s10620-005-1597-x |
| Popis: | The aim of this study was to investigate the arterial hypoxemia in Japanese patients with alcoholic liver disease (ALD) with regard to alcohol consumption and/or disease severity. Hypoxemia was observed in 78% patients with ALD and in all 46 patients with alcoholic liver cirrhosis (ALC) and 33 (56%) of 59 patients with noncirrhotic alcoholic liver disease (NCALD) (P < 0.0001). The partial pressure of oxygen (P aO2) was 71.1 ± 5.2 mm Hg in ALC and 78.7 ± 6.3 mm Hg in NCALD (P < 0.0001). The oxygen consumption in ALD was significantly higher than that in control subjects (P < 0.0001), and a high oxygen consumption was seen in 88% of the patients with ALD, in all 46 ALC patients, and in 46 (78%) of 59 NCALD patients (P < 0.01). Following abstinence from alcohol, the P aO2 and oxygen consumption significantly recovered after day 2 (P < 0.0001), whereas the prothrombin index did not change in either NCALD or ALC patients. Multivariate analysis showed that alcohol consumption and oxygen consumption were significant independent predictors of P aO2. In conclusion, the present findings suggest that increased oxygen consumption due to alcohol ingestion is principally responsible for the hypoxemia in ALD patients. |
| Databáze: | OpenAIRE |
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