Treatment-emergent depression and anxiety between peginterferon alpha-2a versus alpha-2b plus ribavirin for chronic hepatitis C
| Autor: | Cho-Li Yen, Chih-Ken Chen, Jia-Jang Chang, Liang-Jen Wang, Ching-Jung Liu, Rong-Nan Chien, Tsung-Shih Lee, S. C. Chen, Li-Wei Chen |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty China Alcohol use disorder Anxiety Interferon alpha-2 Hospital Anxiety and Depression Scale Antiviral Agents Polyethylene Glycols 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Ribavirin Medicine Humans 030212 general & internal medicine Prospective Studies Prospective cohort study Depression (differential diagnoses) business.industry Depression Incidence Interferon-alpha Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Recombinant Proteins Psychiatry and Mental health Regimen chemistry Interferon 030211 gastroenterology & hepatology Drug Therapy Combination Female medicine.symptom business Research Article |
| Zdroj: | BMC Psychiatry |
| ISSN: | 1471-244X |
| Popis: | This study investigates differences in depression and anxiety between patients with chronic hepatitis C who are treated with peginterferon alpha-2a (PegIFN-α-2a) plus ribavirin and those who are treated with peginterferon alpha-2b (PegIFN-α-2b) plus ribavirin. In this 24 week, non-randomized, observational, prospective study, 55 patients with chronic hepatitis C were treated with PegIFN-α-2a plus ribavirin (Group 1), and 26 patients were treated with PegIFN-α-2b plus ribavirin (Group 2). All patients underwent assessment using the Hospital Anxiety and Depression Scale (HADS) at the baseline and at weeks 4, 12 and 24. Patients with depression scores (HADS-D) ≥ 8 and anxiety scores (HADS-A) ≥ 8 were defined as having depression and anxiety, respectively. The factors that were associated with depression and anxiety during the 24 week antiviral treatment were determined. During the 24 week antiviral treatment, the proportion of patients with depression significantly increased over time in both groups (Group 1: p = 0.048; Group 2: p = 0.044). The proportion of patients with anxiety did not significantly change during the follow-up period in either group. Incidences of depression or anxiety did not differ significantly between Group 1 and Group 2. A history of alcohol use disorder was an independent predictor of depression at week 12 (p |
| Databáze: | OpenAIRE |
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