Cell-Surface-Bound Circulating DNA as a Prognostic Factor in Lung Cancer

Autor:	Olga E. Bryzgunova, Pavel P. Laktionov, Elena Y. Rykova, Aleksandr A. Zav'ialov, Nikolai V. Litviakov, S. N. Tamkovich, Aleksey Yu. Dobrodeev, Valentin V. Vlassov, Nadezhda V. Cherdyntseva, Tuzikov Sa
Rok vydání:	2008
Předmět:	Male Oncology Prognostic factor medicine.medical_specialty Poor prognosis Lung Neoplasms General Neuroscience Cell DNA Disease Biology Prognosis medicine.disease General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound medicine.anatomical_structure History and Philosophy of Science chemistry Internal medicine medicine Humans Circulating DNA In patient Lung cancer
Zdroj:	Annals of the New York Academy of Sciences. 1137:214-217
ISSN:	1749-6632 0077-8923
DOI:	10.1196/annals.1448.042
Popis:	Since the mortality of lung cancer patients remains very high, development of prognostic methods essential for efficient therapy is an immediate task. This study was designed to assess the value of circulating DNA (cirDNA) in blood as a prognostic marker in patients with non-small cell lung cancer. The average concentration of cirDNA in plasma was shown to be similar in healthy donors and lung cancer patients. However, the concentration of cell-surface-bound circulating DNA (csb-cirDNA) in lung cancer patients is significantly lower than that found in healthy donors (P < 0.0001) and correlates with a poor prognosis of tumor disease. Quantification of the cell-surface-bound DNA in blood of untreated patients allows persons with a poor prognosis of tumor disease to be detected with 94% sensitivity and 50% specificity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cdd02f616518e650ea7d6488237148 https://doi.org/10.1196/annals.1448.042 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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