Clinical Features and Treatment Outcomes of Cerebral Arteriovenous Malformation Associated With Moyamoya Disease
| Autor: | Jeong Eun Kim, Hangeul Park, Jung Eun Cheon, Eun Jung Lee, Seung-Ki Kim, Hyun Seung Kang |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Intracranial Arteriovenous Malformations Male Gamma-knife surgery medicine.medical_specialty Adolescent medicine.medical_treatment Revascularization Young Adult Humans Medicine Moyamoya disease Karnofsky Performance Status Cerebral perfusion pressure Stage (cooking) Child Aged medicine.diagnostic_test business.industry Arteriovenous malformation medicine.disease Treatment Outcome Bypass surgery Female Surgery Neurology (clinical) Radiology Moyamoya Disease business Cerebral angiography |
| Zdroj: | World Neurosurgery. 154:e633-e640 |
| ISSN: | 1878-8750 |
| Popis: | Background Cerebral arteriovenous malformation (AVM) can rarely occur in conjunction with moyamoya disease (MMD). There is still no consensus on how to treat AVM when accompanied by MMD. In this study, we assessed the clinical features and suggested appropriate management when AVM was combined with MMD. Methods From August 1994 to December 2020, 7 out of 4004 patients with MMD were found to have AVM. The Karnofsky Performance Scale (KPS) was used to evaluate the clinical outcomes of AVM and MMD. KPS greater than 80 was classified as a good outcome. In addition, the radiologic outcomes of the patients were evaluated. Results The incidence of AVM with MMD was 1.7 per 1000 persons. Five patients underwent bypass surgery for MMD, and 5 patients underwent Gamma Knife surgery (GKS) for concurrent AVM. Postoperative perfusion magnetic resonance imaging and brain single photon emission computerized tomography showed improved cerebral hemodynamics in 4 out of 7 territories. Postoperative cerebral angiography showed good revascularization in 4 out of 8 territories. After GKS, 4 patients showed complete obliteration, and 1 patient showed a significantly decreased AVM size. Six patients showed favorable clinical outcomes (KPS 80–100), and 1 patient with delayed GKS for AVM had a poor outcome (KPS 20) due to AVM rupture. Conclusions In this study, AVM tended to occur where the angiographic stage of MMD was higher. When AVM is combined with MMD, MMD bypass surgery is recommended based on symptoms and cerebral perfusion status. For AVM, less invasive but effective treatments, such as GKS, should be implemented as soon as possible. |
| Databáze: | OpenAIRE |
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