Variation of Transaminases, HCV-RNA Levels and Th1/Th2 Cytokine Production during the Post-Partum Period in Pregnant Women with Chronic Hepatitis C

Autor:	Ángel Carazo, J. Casado, Ana Abril-Molina, J.L. Viota, A. Gila, Laura Sanjuan-Nuñez, Javier Salmerón, Rosa Quiles-Pérez, Josefa León, María Angustias Salmerón-Ruiz, Paloma Muñoz-de-Rueda, Ana Belén Barragán Martín, S. M. Jiménez-Ruiz, Ángeles Ruiz-Extremera, José Antonio Muñoz-Gámez, Esther Ocete-Hita, Esther José Pavón-Castillero
Přispěvatelé:	[Ruiz-Extremera,A] Paediatric Unit, San Cecilio University Hospital, Granada, Spain. [Ruiz-Extremera,A, Muñoz-de-Rueda,P, Quiles-Pérez,R, Gila,A, Ocete-Hita,E, León,J, Salmerón,J] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Ciberehd, Granada. [Ruiz-Extremera,A, Ocete-Hita,E] Paediatric Unit, Granada University, Granada, Spain. [Muñoz-Gámez,JA, Pavón-Castillero,EJ, Carazo,A, Jimenez-Ruiz,SM, Casado,J, Martín,AB, Sanjuán-Nuñez,L, Lopez Viota,J, León,J, Salmeron,J] Clinical Management Unit of Digestive Disease, San Cecilio University Hospital, Granada, Spain. [Abril-Molina,A, Ocete-Hita,E] Paediatric Unit, Virgen de las Nieves Hospital, Granada, Spain. [Salmerón-Ruiz,MA] Paediatric Unit, La Paz University Hospital, Madrid, Spain. [Jimenez-Ruiz,SM, Sanjuán-Núñez,L, Salmerón,J] Medicine Department, Granada University, Granada, Spain.
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Postpartum Period [Medical Subject Headings] Diseases::Virus Diseases::Hepatitis Viral Human::Hepatitis C::Hepatitis C Chronic [Medical Subject Headings] medicine.medical_treatment Organisms::Viruses::Hepatitis Viruses::Hepacivirus [Medical Subject Headings] lcsh:Medicine Physiology Chemicals and Drugs::Amino Acids Peptides and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins [Medical Subject Headings] Hepacivirus medicine.disease_cause Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Evolutionary immunology Liver disease Pregnancy Interleucinas Medicine Viral load lcsh:Science Children Th1-Th2 Balance Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings] Alanina Transaminasa Multidisciplinary biology Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Th1-Th2 Balance [Medical Subject Headings] Postpartum Period Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Nitrogenous Group Transferases::Transaminases::Alanine Transaminase [Medical Subject Headings] virus diseases Alanine Transaminase Hepatitis C Blood Cytokine Cytokines RNA Viral Female Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings] Research Article Adult Genotype Hepatitis C virus Mothers Período de Postparto Named Groups::Persons::Age Groups::Adult [Medical Subject Headings] Humans Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleic Acids::RNA::RNA Viral [Medical Subject Headings] Viral evolution business.industry Interleukins lcsh:R Hepatitis C Chronic medicine.disease Liver disease and pregnancy digestive system diseases Infectious Disease Transmission Vertical Check Tags::Female [Medical Subject Headings] Alanine transaminase Immunology biology.protein lcsh:Q Interferons ARN Viral business Postpartum period
Zdroj:	PLoS ONE PLoS ONE, Vol 8, Iss 10, p e75613 (2013) Digibug. Repositorio Institucional de la Universidad de Granada instname
ISSN:	1932-6203
Popis:	This study analyses the evolution of liver disease in women with chronic hepatitis C during the third trimester of pregnancy and the post-partum period, as a natural model of immune modulation and reconstitution. Of the 122 mothers recruited to this study, 89 were HCV-RNA+ve/HIV-ve and 33 were HCV-RNA-ve/HIV-ve/HCVantibody+ve and all were tested during the third trimester of pregnancy, at delivery and post-delivery. The HCV-RNA+ve mothers were categorized as either Type-A (66%), with an increase in ALT levels in the post-partum period (>40 U/L; P This work was supported by the Fondo de Investigaciones Sanitarias (FIS, Instituto de Salud Carlos III), [grant number PI080704]; Consejería de Salud (SAS), Junta de Andalucía, [grant number SAS111213] and Ciberehd (Ciber de Enfermedades Hepáticas y Digestivas (Instituto de Salud Carlos III).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cc2e05f67a5c022f3468c925bef260 http://europepmc.org/articles/PMC3794969 Zobrazit plný text záznamu Plný text ve formátu PDF