Addition of dexmedetomidine to ropivacaine for local infiltration anaesthesia improves analgesic efficacy after tonsillectomy and adenoidectomy: A randomized controlled trial
| Autor: | Buhuai Dong, Zanqing Wu, Zhenguo Luo, Jianhong Hao |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Time Factors medicine.medical_treatment Analgesic law.invention Adenoidectomy 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial law 030225 pediatrics medicine Humans Pain Management Ropivacaine General anaesthesia Anesthetics Local Dexmedetomidine Child 030223 otorhinolaryngology Acetaminophen Pain Measurement Tonsillectomy Pain Postoperative business.industry General Medicine Analgesics Non-Narcotic Otorhinolaryngology Child Preschool Anesthesia Pediatrics Perinatology and Child Health FLACC scale Female business Anesthesia Local medicine.drug |
| Zdroj: | International Journal of Pediatric Otorhinolaryngology. 137:110168 |
| ISSN: | 0165-5876 |
| DOI: | 10.1016/j.ijporl.2020.110168 |
| Popis: | Objectives The aim of this study was to determine whether the addition of dexmedetomidine to ropivacaine for local infiltration anaesthesia was more effective than ropivacaine alone in attenuating pain after tonsillectomy and adenoidectomy. Methods This was a double-blind randomized clinical trial. One hundred and twenty children scheduled for tonsillectomy and adenoidectomy using a combination of general anaesthesia and local infiltration anaesthesia were randomized into the dexmedetomidine plus ropivacaine group (DR) and ropivacaine group (R). The children were locally infiltrated with 1 μg kg−1 dexmedetomidine and 0.25% ropivacaine in the DR group or 0.25% ropivacaine alone in the R group. In both groups, local infiltration anaesthesia was performed using 5 ml of solution. The pain scores were recorded at the 1st, 4th, 8th, 12th, 16th, 20th, and 24th hours after surgery using the Face Legs Activity Cry Consolability (FLACC) scale. When the pain score exceeded 4, paracetamol syrup (15 mg kg−1) was administered as a rescue analgesic. Time to the first administration of analgesic was recorded. Results 8th, 16th, 20th, and 24th hours after surgery, the children in the DR group had lower pain scores than those in the R group (P Conclusion The addition of dexmedetomidine to ropivacaine for local infiltration anaesthesia effectively improved the efficacy of analgesia and extended the duration of analgesia after tonsillectomy and adenoidectomy. |
| Databáze: | OpenAIRE |
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