Peptide-based targeted therapeutics and apoptosis imaging probes for cancer therapy
| Autor: | Md. Enamul Haque, Gowri Rangaswamy Gunassekaran, Byung-Heon Lee, Fatima Khan, Smriti Gurung, Lianhua Chi, Sri Murugan Poongkavithai Vadevoo, Uttapol Permpoon |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Phage display Cancer therapy Peptide Apoptosis 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems In vivo PD-L1 Neoplasms Drug Discovery Medicine Animals Humans Amino Acid Sequence Fluorescent Dyes chemistry.chemical_classification Clinical Trials as Topic biology business.industry Immunogenicity Organic Chemistry Apoptosis imaging Peptide Fragments 030104 developmental biology chemistry 030220 oncology & carcinogenesis biology.protein Cancer research Molecular Medicine Circulation time business |
| Zdroj: | Archives of pharmacal research. 42(2) |
| ISSN: | 1976-3786 |
| Popis: | Peptides have advantages over antibodies in terms of deep tissue penetration, low immunogenicity, and cost-effective production, but they have short circulation time and poor stability in vivo. Peptides have been extensively used as targeting moieties for the delivery of drug-loaded nanoparticles and function as targeted therapeutics in cancer treatment. Here, we review peptides that are exploited as targeted therapeutics in cancer therapy and apoptosis imaging probes for the monitoring of treatment responses. |
| Databáze: | OpenAIRE |
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