Conventional Dendritic Cells Are Required for the Activation of Helper-Dependent CD8 T Cell Responses to a Model Antigen After Cutaneous Vaccination with Lentiviral Vectors
| Autor: | Ronjon Chakraverty, Clare L. Bennett, David Escors, Hugh D. Goold, Thomas Conlan |
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| Rok vydání: | 2011 |
| Předmět: |
Male
T cell medicine.medical_treatment Genetic Vectors Immunology Endogeny CD8-Positive T-Lymphocytes Biology Lymphocyte Activation Article Mice Transduction (genetics) Antigen Cancer immunotherapy Cell Line Tumor medicine Animals Humans Immunology and Allergy Cytotoxic T cell Diphtheria Toxin Antigens Lymph node Mice Knockout Immunity Cellular Effector Lentivirus Vaccination Dendritic Cells Neoplasms Experimental T-Lymphocytes Helper-Inducer Flow Cytometry Mice Inbred C57BL HEK293 Cells medicine.anatomical_structure Cytokines Female Immunologic Memory |
| Zdroj: | The Journal of Immunology. 186:4565-4572 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Cutaneous vaccination with lentiviral vectors generates systemic CD8 T cell responses that have the potential to eradicate tumors for cancer immunotherapy. However, although s.c. immunization with |
| Databáze: | OpenAIRE |
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