Brain arteriolosclerosis
| Autor: | Brittney L. Blevins, Harry V. Vinters, Seth Love, Donna M. Wilcock, Lea T. Grinberg, Julie A. Schneider, Rajesh N. Kalaria, Yuriko Katsumata, Brian T. Gold, Danny J. J. Wang, Samantha J. Ma, Lincoln M. P. Shade, David W. Fardo, Anika M. S. Hartz, Gregory A. Jicha, Karin B. Nelson, Shino D. Magaki, Frederick A. Schmitt, Merilee A. Teylan, Eseosa T. Ighodaro, Panhavuth Phe, Erin L. Abner, Matthew D. Cykowski, Linda J. Van Eldik, Peter T. Nelson |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Aging
senescence Clinical Sciences cAVU Neuroimaging Neurodegenerative Alzheimer's Disease Article Pathology and Forensic Medicine Cellular and Molecular Neuroscience Vascular Cognitive Impairment/Dementia 80 and over Acquired Cognitive Impairment 2.1 Biological and endogenous factors Animals Humans Aetiology Alzheimer's Disease Related Dementias (ADRD) Aged Aged 80 and over neuropathology Neurology & Neurosurgery neuroimaging arteriosclerosis Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Brain Intracranial Arteriosclerosis Brain Disorders Arterioles Cerebral Amyloid Angiopathy Neurological Dementia Mental health Neurology (clinical) Cognition Disorders SVD |
| Zdroj: | Blevins, B L, Vinters, H V, Love, S, Wilcock, D M, Grinberg, L T, Schneider, J A, Kalaria, R N, Katsumata, Y, Gold, B T, Wang, D J J, Ma, S J, Shade, L M P, Fardo, D W, Hartz, A M S, Jicha, G A, Nelson, K B, Magaki, S D, Schmitt, F A, Teylan, M A, Ighodaro, E T, Phe, P, Abner, E L, Cykowski, M D, Van Eldik, L J & Nelson, P T 2021, ' Brain arteriolosclerosis ', Acta Neuropathologica, vol. 141, no. 1, pp. 1-24 . https://doi.org/10.1007/s00401-020-02235-6 Acta Neuropathol Acta neuropathologica, vol 141, iss 1 |
| Popis: | Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall thickening, is a common finding at autopsy in aged persons and is associated with cognitive impairment. Hypertension and diabetes are widely recognized as risk factors for B-ASC. Recent research indicates other and more complex risk factors and pathogenetic mechanisms. Here, we describe aspects of the unique architecture of brain arterioles, histomorphologic features of B-ASC, relevant neuroimaging findings, epidemiology and association with aging, established genetic risk factors, and the co-occurrence of B-ASC with other neuropathologic conditions such as Alzheimer's disease and limbic-predominant age-related TDP-43 encephalopathy (LATE). There may also be complex physiologic interactions between metabolic syndrome (e.g., hypertension and inflammation) and brain arteriolar pathology. Although there is no universally applied diagnostic methodology, several classification schemes and neuroimaging techniques are used to diagnose and categorize cerebral small vessel disease pathologies that include B-ASC, microinfarcts, microbleeds, lacunar infarcts, and cerebral amyloid angiopathy (CAA). In clinical-pathologic studies that factored incomorbid diseases, B-ASC was independently associated with impairments of global cognition, episodic memory, working memory, and perceptual speed, and has been linked to autonomic dysfunction and motor symptoms including parkinsonism. We conclude by discussing critical knowledge gaps related to B-ASC and suggest that there are probably subcategories of B-ASC that differ in pathogenesis. Observed in over 80% of autopsied individuals beyond 80years of age, B-ASC is a complex and under-studied contributor to neurologic disability. |
| Databáze: | OpenAIRE |
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