A Staphylococcus aureus Regulatory System that Responds to Host Heme and Modulates Virulence
| Autor: | Eric P. Skaar, Paul M. Dunman, Devin L. Stauff, Victor J. Torres, Sebastian Joyce, Laura E. Gordy, Gleb Pishchany, Juan M. Iturregui, Jelena S. Bezbradica, Kelsi L. Anderson |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Staphylococcus aureus
Cancer Research MICROBIO Acclimatization Iron Virulence Heme Environment medicine.disease_cause Microbiology Enterococcus faecalis 03 medical and health sciences chemistry.chemical_compound Listeria monocytogenes Virology Immunology and Microbiology(all) medicine Molecular Biology 030304 developmental biology 0303 health sciences Innate immune system biology 030306 microbiology biology.organism_classification Phenotype 3. Good health Bacillus anthracis chemistry Parasitology |
| Popis: | SummaryStaphylococcus aureus, a bacterium responsible for tremendous morbidity and mortality, exists as a harmless commensal in approximately 25% of humans. Identifying the molecular machinery activated upon infection is central to understanding staphylococcal pathogenesis. We describe the heme sensor system (HssRS) that responds to heme exposure and activates expression of the heme-regulated transporter (HrtAB). Inactivation of the Hss or Hrt systems leads to increased virulence in a vertebrate infection model, a phenotype that is associated with an inhibited innate immune response. We suggest that the coordinated activity of Hss and Hrt allows S. aureus to sense internal host tissues, resulting in tempered virulence to avoid excessive host tissue damage. Further, genomic analyses have identified orthologous Hss and Hrt systems in Bacillus anthracis, Listeria monocytogenes, and Enterococcus faecalis, suggesting a conserved regulatory system by which Gram-positive pathogens sense heme as a molecular marker of internal host tissue and modulate virulence. |
| Databáze: | OpenAIRE |
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